Mackillop W J
Cancer Lett. 1985 Jul;27(3):315-22. doi: 10.1016/0304-3835(85)90190-9.
The doses of radiation and 43 degrees C hyperthermia required to produce 90% killing of a human bladder cancer cell line were determined using a classical colony assay. The growth rate of survivors was then described by carrying out colony-size analysis at sequential times after treatment. It was demonstrated that those cells which initially survive radiation frequently show sustained growth delay and that their progeny may stop growing after a few generations of cell division. After an 'equilethal' dose of hyperthermia there is transient growth delay but there is no long term loss of reproductive integrity in the survivors.
使用经典集落形成试验确定杀死一种人膀胱癌细胞系90%所需的辐射剂量和43摄氏度热疗温度。然后，通过在治疗后的连续时间进行集落大小分析来描述存活细胞的生长速率。结果表明，那些最初在辐射后存活下来的细胞经常表现出持续的生长延迟，并且它们的后代可能在几代细胞分裂后停止生长。在“等效致死”剂量的热疗后，存在短暂的生长延迟，但存活细胞没有长期的生殖完整性丧失。
