Fischer S M, Hardin L, Klein-Szanto A, Slaga T J
Cancer Lett. 1985 Jul;27(3):323-7. doi: 10.1016/0304-3835(85)90191-0.
The semi-synthetic phorbol ester 12-O-retinoyl phorbol 13-acetate (RPA) was tested for activity as a complete tumor promoter, as well as for first or second stage promotion activity, in the skin of SENCAR mice. Unlike in NMRI mice where RPA has been reported to act only as a second stage promoter, in SENCAR mice it has moderate complete promoting activity as well as second stage activity. RPA also induces epidermal hyperplasia and an increase in the number of dark basal keratinocytes.
在SENCAR小鼠的皮肤中，对半合成佛波酯12 - O - 视黄酰佛波醇13 - 乙酸酯（RPA）作为完全肿瘤促进剂的活性以及第一阶段或第二阶段促进活性进行了测试。与在NMRI小鼠中报道的RPA仅作为第二阶段促进剂不同，在SENCAR小鼠中，它具有适度的完全促进活性以及第二阶段活性。RPA还可诱导表皮增生和深色基底角质形成细胞数量增加。
