Oxenham Adrienne, Stevenson Annabel
Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Department of Dermatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Australas J Dermatol. 2025 Aug;66(5):247-257. doi: 10.1111/ajd.14463. Epub 2025 Apr 1.
Frontal fibrosing alopecia (FFA) is a form of cicatricial alopecia that is being increasingly diagnosed in recent years. It predominantly affects post-menopausal women of various ethnic backgrounds, but cases have also been reported in pre-menopausal women and rarely in men. Eleven familial cases of FFA have been published in the literature, with some authors raising speculation about potential genetic predisposition or shared exposure to environmental factors as triggers for the condition. Despite this, there remains a lack of detailed characterisation of the clinical features specific to familial cases of FFA. In this report, we aim to contribute to the understanding of FFA by presenting the first Australian case of familial FFA involving a mother and her daughter, while also attempting to define the clinical distinguishing features in familial FFA and sporadic FFA.
额部纤维性秃发（FFA）是瘢痕性秃发的一种形式，近年来其诊断率日益增加。它主要影响不同种族背景的绝经后女性，但绝经前女性病例也有报道，男性则极为罕见。文献中已发表了11例FFA家族病例，一些作者推测可能存在遗传易感性或共同暴露于环境因素作为该病的触发因素。尽管如此，FFA家族病例的特定临床特征仍缺乏详细描述。在本报告中，我们旨在通过呈现澳大利亚首例涉及母亲和女儿的家族性FFA病例，促进对FFA的理解，同时试图明确家族性FFA和散发性FFA的临床鉴别特征。
