Starace Michela Valeria Rita, Pampaloni Francesca, Iorizzo Matilde, Apalla Zoe, Asfour Leila, Freites-Martinez Azael, Ioannides Dimitrios, Kelati Awatef, Piraccini Bianca Maria, Rakowska Adriana, Rudnicka Lidia, Sechi Andrea, Seyed Jafari Seyed Morteza, Takwale Anita, Therianou Anastasia, Waśkiel-Burnat Anna, Katoulis Alexander
Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Int J Dermatol. 2025 Apr 10. doi: 10.1111/ijd.17780.
Frontal fibrosing alopecia (FFA) has been defined as a lichen planopilaris (LPP) variant, and both are characterized by lymphocytic scarring alopecia. Despite histopathological similarities, they differ clinically, suggesting potentially different pathogenetic factors. This Delphi study aimed to collect expert opinions to clarify the relationship between FFA and LPP.
The Delphi method was employed via an anonymous survey among experts in hair disorders from the Hair Diseases Task Force of the European Academy of Dermatology and Venereology (EADV), ensuring broad international representation. Two rounds of online questionnaires assessed the definition, clinical presentation, diagnosis, and management of LPP and FFA. The statements, developed based on an extensive literature review, were validated by the core expert panel. A 5-point Likert scale was utilized to quantify agreement levels, with strong consensus defined as ≥ 75% agreement or disagreement. Statements lacking strong consensus in the first round were revised and merged for inclusion in the second round.
Seventeen experts from seven countries joined the Delphi consensus process. In the first round, 65 statements underwent qualitative content analysis, yielding strong consensus in 30.7% of cases. Participants provided written justifications for their assessments. In the second round, an increased consensus rate (53.7%) was reached after the expert panel statement's revision.
This study confirms that FFA and LPP are clinical variants within the same lichenoid spectrum. While moderate consensus supports FFA as a variant of LPP, uncertainties remain regarding its demographic distribution, the presence of vellus hairs, and blue-gray dots. The study refines diagnostic and management approaches but is limited by the absence of dermatopathologists and basic researchers.
额部纤维性秃发(FFA)已被定义为扁平苔藓样毛发角化病(LPP)的一种变体,二者均以淋巴细胞性瘢痕性秃发为特征。尽管组织病理学表现相似,但它们在临床上有所不同,提示可能存在不同的致病因素。这项德尔菲研究旨在收集专家意见,以阐明FFA与LPP之间的关系。
通过对欧洲皮肤病与性病学会(EADV)毛发疾病工作组中毛发疾病专家进行匿名调查来采用德尔菲法,确保具有广泛的国际代表性。两轮在线问卷评估了LPP和FFA的定义、临床表现、诊断和管理。基于广泛的文献综述制定的陈述由核心专家小组进行验证。采用5点李克特量表来量化共识程度,强烈共识定义为≥75%的同意或不同意。第一轮中缺乏强烈共识的陈述进行了修订和合并,以纳入第二轮。
来自七个国家的17名专家参与了德尔菲共识过程。在第一轮中,对65条陈述进行了定性内容分析,30.7%的案例达成了强烈共识。参与者为其评估提供了书面理由。在第二轮中,专家小组陈述修订后达成的共识率有所提高(53.7%)。
本研究证实FFA和LPP是同一苔藓样谱系中的临床变体。虽然中等程度的共识支持FFA作为LPP的一种变体,但在其人口统计学分布、毳毛的存在以及蓝灰色小点方面仍存在不确定性。该研究完善了诊断和管理方法,但因缺乏皮肤病理学家和基础研究人员而受到限制。