van der Gugten A A, Röpcke G, van Nie R, Hilgers J
Cancer Res. 1985 Aug;45(8):3448-53.
Implantation of hypophysial isografts does not lead to induction of mammary tumors in all strains of mice lacking the exogenous murine mammary tumor virus. While O20, C3Hf, and BALB/c females are highly susceptible and C57BL and TSI females are of intermediate susceptibility, the STS females appear to be nearly totally resistant. The resistance of the STS strain is not due to failure of prolactin production by the hypophysial isografts and may therefore be due to a genetically controlled mechanism at target cell level. Neither resistance, i.e., low incidence of mammary tumors (2% in STS), nor susceptibility, i.e., high incidence at low age (93% at 349 days in C3Hf; 83% at 360 days in BALB/c), is dominant. F1 hybrids of strain STS and the two strains C3Hf and BALB/c show high incidences (STS X C3Hf F1, 90%; STS X BALB/c F1, 60%), but the age at which tumors appear (476 and 604 days, respectively) is much higher, suggesting that more than one gene is involved in this type of hormonal carcinogenesis of the mammary gland in mice.
垂体同基因移植物的植入并不会在所有缺乏外源性小鼠乳腺肿瘤病毒的小鼠品系中诱发乳腺肿瘤。虽然O20、C3Hf和BALB/c雌性小鼠高度易感，C57BL和TSI雌性小鼠易感性中等，但STS雌性小鼠似乎几乎完全具有抗性。STS品系的抗性并非由于垂体同基因移植物不能产生催乳素，因此可能是由于靶细胞水平上的一种基因控制机制。抗性（即乳腺肿瘤低发病率，STS中为2%）和易感性（即在低龄时高发病率，C3Hf中349天时为93%；BALB/c中360天时为83%）都不是显性的。STS品系与C3Hf和BALB/c这两个品系的F1代杂种显示出高发病率（STS×C3Hf F1为90%；STS×BALB/c F1为60%），但肿瘤出现的年龄（分别为476天和604天）要高得多，这表明在小鼠乳腺的这种激素致癌作用中涉及多个基因。
