Michalides R, Wagenaar E, Nusse R
J Natl Cancer Inst. 1979 Apr;62(4):935-41.
The radioimmunoprecipitation assay for the murine mammary tumor virus (MuMTV) was used to detect naturally occurring antibodies against MuMTV in 3 groups of highly inbred mouse strains. 1) Some strains had high incidences of mammary tumors, such as strains GR and C3H. Antibodies against MuMTV were detected in the sera of females of these strains at early ages. 2) Some mouse strains had low incidences of mammary tumors with an intermediate MuMTV expression, such as strains C3Hf, RIIIf, and BALB/c. Some females of these strains developed antibodies against MuMTV. Hormone treatment of these mice resulted in an increase in the proportion of mice carrying antibodies against MuMTV. 3) Some mouse strains were MuMTV-free, such as strains O20, C57BL, and Gr-Mtv2-. No antibodies against MuMTV were detected in the sera of these mice. However, antibodies against MuMTV appeared in the sera of these animals after hormone treatment. The presence of a natural humoral immunity toward MuMTV appeared to be related to the expression of MuMTV in the animals.
采用针对小鼠乳腺肿瘤病毒（MuMTV）的放射免疫沉淀试验，检测了3组高度近交系小鼠中天然存在的抗MuMTV抗体。1）一些品系的乳腺肿瘤发病率较高，如GR和C3H品系。在这些品系雌性小鼠的血清中，很早就检测到了抗MuMTV抗体。2）一些小鼠品系的乳腺肿瘤发病率较低，MuMTV表达处于中等水平，如C3Hf、RIIIf和BALB/c品系。这些品系的一些雌性小鼠产生了抗MuMTV抗体。对这些小鼠进行激素处理后，携带抗MuMTV抗体的小鼠比例增加。3）一些小鼠品系不含MuMTV，如O20、C57BL和Gr-Mtv2-品系。在这些小鼠的血清中未检测到抗MuMTV抗体。然而，激素处理后，这些动物的血清中出现了抗MuMTV抗体。对MuMTV天然体液免疫的存在似乎与该病毒在动物体内的表达有关。
