非分裂人二倍体成纤维细胞（HDF）对由循环HDF和HeLa细胞产生的DNA合成诱导剂的反应差异。

Differences in the response of non-dividing human diploid fibroblasts (HDF) to inducers of DNA synthesis generated by cycling HDF and HeLa cells.

作者信息

Rao M V

出版信息

Cell Biol Int Rep. 1985 May;9(5):419-27. doi: 10.1016/0309-1651(85)90150-x.

Abstract

The ability of non-dividing WI-38 cells from different passages to respond to inducers of DNA synthesis generated by other WI-38 cells in G1 or S and HeLa cells in S was studied. The non-dividing cells are refractory to inducers of DNA synthesis generated by WI-38 cells in S but respond to HeLa inducers after a lag period of 3 hours. The WI-38 cells in G1 are not inhibited from entering S in the presence of non-dividing cell nuclei in the heterokaryons.

摘要

研究了来自不同传代的非分裂WI-38细胞对处于G1期或S期的其他WI-38细胞以及处于S期的HeLa细胞所产生的DNA合成诱导剂的反应能力。非分裂细胞对处于S期的WI-38细胞所产生的DNA合成诱导剂具有抗性，但在3小时的延迟期后对HeLa诱导剂有反应。在异核体中存在非分裂细胞核的情况下，处于G1期的WI-38细胞不会被阻止进入S期。