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电子药品信息对疫苗犹豫影响的实验研究

An experimental study on the effects of electronic medicinal product information on vaccine hesitancy.

作者信息

Ingebretsen Carlson Jim, Puppo Federico, Roca-Umbert Ana, Folkvord Frans, Lupiáñez-Villanueva Francisco

机构信息

PredictBy Research and Consulting, Barcelona, Spain.

Tilburg School of Humanities and Digital Sciences, Tilburg University, Tilburg, The Netherlands.

出版信息

Sci Rep. 2025 Apr 1;15(1):11197. doi: 10.1038/s41598-025-96092-6.

DOI:10.1038/s41598-025-96092-6
PMID:40169714
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11961571/
Abstract

Although immunization through vaccination is one of the most successful public health interventions, coverage of some vaccination programs has decreased in recent years due to increased vaccine hesitancy. Cognitive biases have been shown to play an important role in affecting vaccine hesitancy. In this study, we conducted a randomized controlled trial (N = 2000, N = 1000 from Spain and N = 1000 from Bulgaria), where subjects were randomly assigned to one experimental condition. The experimental conditions differed by whether electronic product information (ePI) was presented to the subjects and by the type of information that was made more salient to the patient. The current study showed that the provision of digital information in the form of ePI has important consequences for achieving high vaccination rates. The main result suggests that providing vaccination information in the form of ePI can increase patients' vaccine hesitancy. This effect remained when positive and/or negative information in the ePI was made more salient to the patients. Additionally, we observe that vaccine hesitant individuals spend less time reading ePI. We conclude, by relating the current study to the relevant literature, that salience and information overload could be the main driver of vaccine hesitancy in the context of this study.

摘要

尽管通过疫苗接种进行免疫是最成功的公共卫生干预措施之一,但近年来,由于疫苗犹豫现象增多,一些疫苗接种计划的覆盖率有所下降。认知偏差已被证明在影响疫苗犹豫方面起着重要作用。在本研究中,我们进行了一项随机对照试验(N = 2000,其中1000名来自西班牙,1000名来自保加利亚),受试者被随机分配到一种实验条件下。实验条件因是否向受试者呈现电子产品信息(ePI)以及向患者突出呈现的信息类型而异。当前研究表明,以ePI形式提供数字信息对于实现高疫苗接种率具有重要影响。主要结果表明,以ePI形式提供疫苗接种信息会增加患者的疫苗犹豫程度。当ePI中的正面和/或负面信息更突出地呈现给患者时,这种效果仍然存在。此外,我们观察到对疫苗犹豫的个体阅读ePI的时间较少。通过将当前研究与相关文献联系起来,我们得出结论,在本研究背景下,突出性和信息过载可能是疫苗犹豫的主要驱动因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8117/11961571/315a18f521d4/41598_2025_96092_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8117/11961571/974c321ad050/41598_2025_96092_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8117/11961571/dfaad4d4aee2/41598_2025_96092_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8117/11961571/315a18f521d4/41598_2025_96092_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8117/11961571/974c321ad050/41598_2025_96092_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8117/11961571/dfaad4d4aee2/41598_2025_96092_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8117/11961571/315a18f521d4/41598_2025_96092_Fig3_HTML.jpg

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本文引用的文献

1
Immunization agenda 2030: A global strategy to leave no one behind.《2030年免疫议程:不让任何人掉队的全球战略》
Vaccine. 2024 Apr 8;42 Suppl 1:S5-S14. doi: 10.1016/j.vaccine.2022.11.042.
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Sci Rep. 2024 Feb 7;14(1):3190. doi: 10.1038/s41598-024-52408-6.
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Coverage with Selected Vaccines and Exemption from School Vaccine Requirements Among Children in Kindergarten - United States, 2022-23 School Year.
幼儿园儿童的疫苗接种覆盖情况和学校疫苗要求豁免情况 - 美国,2022-23 学年。
MMWR Morb Mortal Wkly Rep. 2023 Nov 10;72(45):1217-1224. doi: 10.15585/mmwr.mm7245a2.
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The impact of information sources on COVID-19 vaccine hesitancy and resistance in sub-Saharan Africa.信息来源对撒哈拉以南非洲 COVID-19 疫苗犹豫和抵制的影响。
BMC Public Health. 2023 Jan 6;23(1):38. doi: 10.1186/s12889-022-14972-2.
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Confirmation bias and vaccine-related beliefs in the time of COVID-19.新冠疫情期间的确认偏误与疫苗相关信念。
J Public Health (Oxf). 2023 Jun 14;45(2):523-528. doi: 10.1093/pubmed/fdac128.
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[Understanding the behavioural and social drivers of vaccine uptake: introduction and implications of World Health Organization Position Paper, 2022].[理解疫苗接种的行为和社会驱动因素:世界卫生组织2022年立场文件的介绍与影响]
Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Oct 6;56(10):1494-1498. doi: 10.3760/cma.j.cn112150-20220706-00686.
7
Shared understandings of vaccine hesitancy: How perceived risk and trust in vaccination frame individuals' vaccine acceptance.对疫苗犹豫的共同理解:感知风险和对疫苗的信任如何影响个人对疫苗的接受程度。
PLoS One. 2022 Oct 21;17(10):e0276519. doi: 10.1371/journal.pone.0276519. eCollection 2022.
8
Cancer information overload may be a crucial determinant of adjuvant aromatase inhibitor adherence.癌症信息过载可能是辅助性芳香化酶抑制剂依从性的关键决定因素。
Eur Rev Med Pharmacol Sci. 2022 Oct;26(19):7053-7062. doi: 10.26355/eurrev_202210_29889.
9
Comprehensive toxicity screening of Pazarsuyu stream water containing heavy metals and protective role of lycopene.含重金属的帕扎尔舒尤溪的综合毒性筛查及番茄红素的保护作用。
Sci Rep. 2022 Oct 5;12(1):16615. doi: 10.1038/s41598-022-21081-y.
10
Vaccine hesitancy and cognitive biases: Evidence for tailored communication with parents.疫苗犹豫与认知偏差:针对家长进行个性化沟通的证据
Vaccine X. 2022 Jul 2;11:100191. doi: 10.1016/j.jvacx.2022.100191. eCollection 2022 Aug.