2型糖尿病中的新冠病毒疾病（COVID-19）与神经病变
COVID-19 and neuropathy in type 2 diabetes.
作者信息
Ponirakis Georgios, Al-Janahi Ibrahim, Elgassim Einas, Al Obaidan Aisha, Gad Hoda, Petropoulos Ioannis N, Khan Adnan, Zaghloul Hadeel B, Ali Hamda, Siddique Mashhood A, Mohamed Fatima F S, Ahmed Lina H M, Dakroury Youssra, El Shewehy Abeer M M, Al-Thani Shaikha N, Ahmed Farheen, Hussein Rawan, Mahmoud Salah, Salivon Iuliia, Homssi Moayad, Hadid Nebras H, Ali Ateeque Mohamed, Khan Safah, Mahfoud Ziyad R, Zirie Mahmoud A, Bitirgen Gulfidan, Al-Ansari Yousuf, Alhatou Mohammed I, Atkin Stephen L, Malik Rayaz A
机构信息
Department of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
National Diabetes Center, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
出版信息
Sci Rep. 2025 Apr 1;15(1):11188. doi: 10.1038/s41598-025-95133-4.
This study investigated the risk factors for COVID-19 and its impact on diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D). Patients with T2D underwent assessments with the NICE post-COVID questionnaire, DN4 questionnaire, vibration perception threshold (VPT), and corneal confocal microscopy (CCM) before and 11.0 ± 8.9 months after developing COVID-19. Of 76 participants with T2D, 35 (46.1%) developed COVID-19, of whom 8 (22.9%) developed severe COVID-19 and 9 (25.7%) developed long-COVID. The development of COVID-19 was associated with lower systolic blood pressure (P < 0.05). The presence and severity of DPN were not associated with developing COVID-19, severe COVID-19, or long-COVID (P = 0.42-0.94). Women were eight times more likely to develop long-COVID (P < 0.05) and elevated body weight, LDL, and VPT were associated with the development of long-COVID (P < 0.05 - 0.01). The long-COVID group exhibited significant changes in triglycerides and LDL (P < 0.05 for both) and body weight (P < 0.01) at follow-up. Their impact on clinical and neuropathy measures was comparable in patients with and without COVID-19 (P = 0.08-0.99). There was a significant reduction in corneal nerve measures (P < 0.05-0.0001) in patients with and without COVID-19. A low systolic blood pressure, altered lipids, body weight, higher VPT, and gender may determine the impact of COVID-19 in patients with T2D, but there was no evidence of an impact of COVID-19 on the development or progression of DPN.
本研究调查了2型糖尿病（T2D）患者中新型冠状病毒肺炎（COVID-19）的危险因素及其对糖尿病周围神经病变（DPN）的影响。T2D患者在感染COVID-19之前以及感染后11.0±8.9个月接受了英国国家卫生与临床优化研究所（NICE）COVID-19后调查问卷、DN4问卷、振动觉阈值（VPT）和角膜共聚焦显微镜（CCM）评估。在76名T2D参与者中，35名（46.1%）感染了COVID-19，其中8名（22.9%）发展为重症COVID-19，9名（25.7%）发展为新冠后综合征。COVID-19的发生与较低的收缩压相关（P<0.05）。DPN的存在和严重程度与感染COVID-19、重症COVID-19或新冠后综合征无关（P=0.42-0.94）。女性患新冠后综合征的可能性高八倍（P<0.05），体重增加、低密度脂蛋白（LDL）升高和VPT与新冠后综合征的发生相关（P<0.05-0.01）。在随访时，新冠后综合征组的甘油三酯和LDL均有显著变化（两者P<0.05），体重也有显著变化（P<0.01）。在有和没有COVID-19的患者中，它们对临床和神经病变指标的影响相当（P=0.08-0.99）。有和没有COVID-19的患者角膜神经指标均有显著降低（P<0.05-0.0001）。低收缩压、血脂改变、体重、较高的VPT和性别可能决定了COVID-19对T2D患者的影响，但没有证据表明COVID-19对DPN的发生或进展有影响。
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