Wu Zhenzhu, Chen Yi, Ma Yingying, Xiao Tingting, Xiao Yonghong
Department of Infectious Disease, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325025, China.
Department of Gastroenterology, Wenzhou People's Hospital, Wenzhou, 325000, China.
BMC Infect Dis. 2025 Apr 1;25(1):455. doi: 10.1186/s12879-025-10846-1.
Infective endocarditis (IE) has attracted widespread public attention. However, studies on its economic burden remain scarce.
This retrospective study aimed to collect data on the clinical characteristics of patients with IE from electronic medical records and estimate the economic burden with disability-adjusted life years (DALYs). Additionally, the changing trend of IE from 2007 to 2016 and differences between native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE) on economic burden were analyzed.
There were 407 patients with IE enrolled in this study. The total DALY loss was 1710.2. The average indirect economic burden ranged from $6253.27 to $14766.34 from 2007 to 2016 showing a stable trend, which was 1.67 to 2.46 times the annual per gross domestic product (GDP). Interestingly, the average indirect economic burden for females ranged from $5941.37 to $17261.07 with a significant upward trend during this period (P = 0.035).The average DALY loss and indirect economic burden were highest in patient aged ≤ 19 (4.82, $21486.12) and lowest in those aged 80-89(0.46, $342.87), decreasing significantly with age(both P<0.001). Finally, there were no significant differences in the average DALY loss and indirect economic burden between the PVE group and NVE group during this period (2.69 vs. 2.63, P = 0.740; $9224.0vs. $11789.4, P = 0.136).
The DALY loss and indirect economic burden associated with IE were notably high, particularly among younger patients and females. These findings highlight the need for targeted preventive care and early interventions, especially for youth and gender-specific strategies, to reduce disparities in IE burden.
感染性心内膜炎（IE）已引起广泛的公众关注。然而，关于其经济负担的研究仍然很少。
这项回顾性研究旨在从电子病历中收集IE患者的临床特征数据，并用伤残调整生命年（DALYs）估算经济负担。此外，分析了2007年至2016年IE的变化趋势以及自然瓣膜心内膜炎（NVE）和人工瓣膜心内膜炎（PVE）在经济负担上的差异。
本研究纳入了407例IE患者。总的DALY损失为1710.2。2007年至2016年间接经济负担平均为6253.27美元至14766.34美元，呈稳定趋势，是年人均国内生产总值（GDP）的1.67至2.46倍。有趣的是，女性的间接经济负担平均为5941.37美元至17261.07美元，在此期间呈显著上升趋势（P = 0.035）。平均DALY损失和间接经济负担在年龄≤19岁的患者中最高（4.82，21486.12美元），在80 - 89岁的患者中最低（0.46，342.87美元），随年龄显著下降（P均<0.001）。最后，在此期间PVE组和NVE组的平均DALY损失和间接经济负担无显著差异（2.69对2.63，P = 0.740；9224.0美元对11789.4美元，P = 0.136）。
与IE相关的DALY损失和间接经济负担显著较高，尤其是在年轻患者和女性中。这些发现凸显了有针对性的预防保健和早期干预的必要性，特别是针对青年和特定性别的策略，以减少IE负担方面的差异。
