Çaydere Muzaffer, Şahin Ömer
Department of Pathology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.
Department of Neurosurgery, Bestepe State Hospital, Ankara, 06560, Turkey.
J Orthop Surg Res. 2025 Apr 1;20(1):331. doi: 10.1186/s13018-025-05758-4.
Halofuginone is an antiprotozoal drug with antifibrotic and anti-inflammatory properties. The aim of our study was to determine the effects of halofuginone on nerve recovery in sciatic nerve injury and compare it with steroid treatment.
The left sciatic nerves of Sham subjects were exposed without intervention. The nerves of trauma animals were transected and sutured. In the methylprednisolone group and in the trauma group, after nerve transection and repair, 1 mg/kg methylprednisolone per day was administered intraperitoneally for seven days; in the halofuginone group and in the trauma group, after nerve transection and repair, 0.2 mg/kg halofuginone per day was administered orally by gavage for seven days. The rats were functionally evaluated at 4 and 8 weeks through walking path analysis. Pathological-morphometric, immunostaining-quantitative, and muscle weight measurements were performed at 8 weeks.
Compared with the trauma group, the methylprednisolone and the halofuginone groups had better functional outcomes (p < 0.001). Statistically significant difference was found in comparisons of the pathological and immunostaining results of the methylprednisolone and halofuginone groups (Respectively, nerve diameter (p = 0.007) and edema (P = 0.009)).
Halofuginone positively contributed to recovery after sciatic nerve injury.
Not applicable.
常山酮是一种具有抗纤维化和抗炎特性的抗原虫药物。我们研究的目的是确定常山酮对坐骨神经损伤后神经恢复的影响，并将其与类固醇治疗进行比较。
假手术组动物的左侧坐骨神经暴露但不进行干预。创伤组动物的神经被切断并缝合。在甲基泼尼松龙组和创伤组中，神经切断并修复后，每天腹腔注射1mg/kg甲基泼尼松龙，持续7天；在常山酮组和创伤组中，神经切断并修复后，每天经口灌胃给予0.2mg/kg常山酮，持续7天。在4周和8周时通过行走路径分析对大鼠进行功能评估。在8周时进行病理形态学、免疫染色定量和肌肉重量测量。
与创伤组相比，甲基泼尼松龙组和常山酮组的功能结局更好（p < 0.001）。甲基泼尼松龙组和常山酮组的病理和免疫染色结果比较存在统计学显著差异（分别为神经直径（p = 0.007）和水肿（P = 0.009））。
常山酮对坐骨神经损伤后的恢复有积极作用。
不适用。
