Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan.
Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian Province, 361021 China.
Int J Biol Sci. 2020 Jan 1;16(1):116-134. doi: 10.7150/ijbs.35653. eCollection 2020.
Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and even lifelong disability. After lesion, the neuronal cell body becomes disconnected from the axon's distal portion to the injury site leading to the axonal degeneration and dismantlement of neuromuscular junctions of targeted muscles. In spite of extensive research on this aspect, complete functional recovery still remains a challenge to be resolved. This review highlights detailed pathophysiological events after an injury to a peripheral nerve and the associated factors that can either hinder or promote the regenerative machinery. In addition, it throws light on the available therapeutic strategies including supporting therapies, surgical and non-surgical interventions to ameliorate the axonal regeneration, neuronal survival, and reinnervation of peripheral targets. Despite the availability of various treatment options, we are still lacking the optimal treatments for a perfect and complete functional regain. The need for the present age is to discover or design such potent compounds that would be able to execute the complete functional retrieval. In this regard, plant-derived compounds are getting more attention and several recent reports validate their remedial effects. A plethora of plants and plant-derived phytochemicals have been suggested with curative effects against a number of diseases in general and neuronal injury in particular. They can be a ray of hope for the suffering individuals.
周围神经损伤是一种复杂的病症，具有多种症状和体征，如麻木、刺痛、刺痛、悸动、烧灼感或锐痛。周围神经本质上很脆弱，容易因急性压迫或创伤而受损，这可能导致感觉和运动功能缺陷，甚至终身残疾。在损伤后，神经元细胞体与轴突的远端到损伤部位分离，导致轴突变性和靶向肌肉的神经肌肉接头解体。尽管对此进行了广泛的研究，但完全的功能恢复仍然是一个有待解决的挑战。这篇综述强调了周围神经损伤后的详细病理生理事件，以及可能阻碍或促进再生机制的相关因素。此外，它还介绍了现有的治疗策略，包括支持疗法、手术和非手术干预，以改善轴突再生、神经元存活和周围靶标的再神经支配。尽管有多种治疗选择，但我们仍然缺乏完美和完全功能恢复的最佳治疗方法。当今的需要是发现或设计能够执行完全功能恢复的有效化合物。在这方面，植物来源的化合物越来越受到关注，最近的几项报告验证了它们的治疗效果。许多植物和植物源性植物化学物质已被建议对一般疾病，特别是神经元损伤具有治疗效果。它们可能是受苦受难者的一线希望。
