θ波爆发刺激（TBS）对中风患者失语症的影响：一项系统评价和荟萃分析方案

The effect of theta burst stimulation (TBS) on aphasia in stroke patients: a protocol of systematic review and meta-analysis.

作者信息

Fu Hong-Juan, Tang Yong, Wen Xin-Ru, Zhao Wen-Qian, Gao Yi-Qiu, Huang Chen, Zeng Li-Hong, Zhang Shu-Hao, Li Juan, Zuo Guan-Chao

机构信息

Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of TCM, Chengdu, Sichuan, China.

Acupuncture-Moxibustion School of Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

出版信息

Syst Rev. 2025 Apr 1;14(1):75. doi: 10.1186/s13643-025-02823-1.

DOI:10.1186/s13643-025-02823-1

PMID:40170172

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11959958/

Abstract

BACKGROUND

Prior studies have 3suggested that theta burst stimulation (TBS) may be a promising intervention for the rehabilitation of aphasia after stroke. However, the results of these investigations have been inconsistent, with no definitive consensus on its efficacy and safety. Given the inconclusive nature of the existing evidence, this study aims to conduct a comprehensive and systematic review to evaluate the therapeutic effects of TBS on aphasia in stroke patients.

METHODS

We will perform an extensive search of eight online databases from their inception to August 1, 2024, to identify relevant randomized controlled trials (RCTs) that examine the impact of TBS on aphasia in stroke patients. The primary outcome will be the severity of aphasia, assessed using a suite of standardized evaluation tools. Secondary outcomes will include measures of naming, repetition, comprehension, spontaneous speech, aphasia quotient, quality of life, and documentation of adverse events. The review process will involve rigorous study selection, data extraction, risk of bias assessment, and evaluation of the certainty of evidence by two independent reviewers. Data synthesis and statistical analysis will be conducted using Review Manager (RevMan) software, version 5.3. If significant heterogeneity is not detected among the studies, a meta-analysis will be performed. Otherwise, a narrative qualitative summary will be provided. The quality of evidence will be assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) system.

DISCUSSION

This study will be the first systematic review to comprehensively synthesize the existing evidence regarding the application of TBS in the treatment of aphasia in stroke patients. The findings are expected to provide valuable insights for clinicians and policymakers, facilitating the development of more equitable and high-quality healthcare services for this patient population.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO CRD42024521347.

摘要

背景

先前的研究表明，theta爆发刺激（TBS）可能是中风后失语症康复的一种有前景的干预措施。然而，这些研究的结果并不一致，在其疗效和安全性方面尚未达成明确共识。鉴于现有证据的不确定性，本研究旨在进行全面系统的综述，以评估TBS对中风患者失语症的治疗效果。

方法

我们将对八个在线数据库从创建到2024年8月1日进行广泛检索，以识别相关的随机对照试验（RCT），这些试验研究TBS对中风患者失语症的影响。主要结局将是失语症的严重程度，使用一套标准化评估工具进行评估。次要结局将包括命名、复述、理解、自发言语、失语症商数、生活质量的测量以及不良事件的记录。综述过程将包括严格的研究选择、数据提取、偏倚风险评估以及由两名独立评审员对证据确定性的评估。将使用Review Manager（RevMan）软件5.3版进行数据合成和统计分析。如果在研究中未检测到显著异质性，将进行荟萃分析。否则，将提供叙述性定性总结。将使用GRADE（推荐评估、制定和评价分级）系统评估证据质量。