Shi Ji-Hua, Line Pål-Dag, Zhang Shui-Jun, Guo Wen-Zhi
Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
J Inflamm Res. 2025 Mar 28;18:4497-4508. doi: 10.2147/JIR.S506737. eCollection 2025.
Experimental animal models of liver surgery are crucial for understanding human liver physiology and pathogenesis and identifying novel therapeutic modalities for liver disease. Herein, we update the brief summary of the most widely used experimental models and concepts in hepatic surgery, including hepatic ischemia/reperfusion, partial hepatectomy, liver transplantation, techniques and parameters of vascular perfusion of the liver, and using bile duct ligation as a model of cholestasis for the development of liver fibrosis. We focus on surgical aspects of available models for the study of various forms of liver disease. Furthermore, we summarize the translation of experimental liver surgery by highlighting surgical innovations, exploring key molecular mechanisms, and employing emerging treatment strategies.
肝脏手术的实验动物模型对于理解人类肝脏生理学和发病机制以及确定肝病的新型治疗方式至关重要。在此，我们更新了肝脏手术中最广泛使用的实验模型和概念的简要总结，包括肝缺血/再灌注、部分肝切除术、肝移植、肝脏血管灌注技术和参数，以及使用胆管结扎作为肝纤维化发展的胆汁淤积模型。我们专注于用于研究各种肝病形式的现有模型的手术方面。此外，我们通过突出手术创新、探索关键分子机制和采用新兴治疗策略来总结实验性肝脏手术的转化。
