Lee Kang-San, Park Sung-Jin, Kim Dong-Hyun, Chung Seok Won, Kim Jun-Young, Cho Chul-Hyun, Yoon Jong Pil
Department of Orthopedic Surgery, Kyungpook National University Hospital, Daegu, Korea.
Department of Orthopedic Surgery, Konkuk University Medical Center, Seoul, Korea.
Clin Orthop Surg. 2025 Apr;17(2):187-193. doi: 10.4055/cios24301. Epub 2025 Feb 18.
The detrimental effects of hyperlipidemia on the healing of rotator cuff tears are well documented. The proposed underlying mechanisms for these effects include alterations in the extracellular matrix, inflammation, and oxidative stress, which hamper the reparative processes in the affected tendon tissues. Recent therapeutic strategies target these pathways, reflecting a growing body of research dedicated to mitigating these effects and promoting healing. This literature review aims to provide a comprehensive understanding of the pathophysiology underlying rotator cuff tears, examine the interplay between hyperlipidemia and rotator cuff tear healing, synthesize current knowledge on contributing biological mechanisms, and outline potential therapeutic interventions to optimize clinical management and treatment outcomes for patients.
高脂血症对肩袖撕裂愈合的有害影响已有充分记录。这些影响的潜在机制包括细胞外基质的改变、炎症和氧化应激，它们会阻碍受影响肌腱组织的修复过程。最近的治疗策略针对这些途径，这反映出越来越多的研究致力于减轻这些影响并促进愈合。这篇文献综述旨在全面了解肩袖撕裂的病理生理学，研究高脂血症与肩袖撕裂愈合之间的相互作用，综合目前关于相关生物学机制的知识，并概述潜在的治疗干预措施，以优化患者的临床管理和治疗效果。
