Daher Mohammad, Covarrubias Oscar, Lopez Ryan, Boufadel Peter, Hachem Maria Catherine Rita, Zalaquett Ziad, Fares Mohamad Y, Abboud Joseph A
Rothman Orthopaedic Institute, Philadelphia, PA, USA.
Department of Orthopedics, Brown University, Providence, RI, USA.
Clin Shoulder Elb. 2025 Feb;28(1):93-102. doi: 10.5397/cise.2024.00220. Epub 2024 Jul 30.
Vitamin D deficiency is highly prevalent in the general population and is associated with various chronic health conditions. In addition to its role in bone mineralization, Vitamin D has various physiological effects that may impact the pathogenesis of shoulder pathologies. Vitamin D deficiency may also affect outcomes after shoulder surgeries, such as rotator cuff repair and total shoulder arthroplasty. Vitamin D plays a role in tissue healing, bone growth, and maintenance of homeostasis in skeletal muscle cells. Vitamin D also has anti-inflammatory effects that are important to rotator cuff health. Vitamin D deficiency is highly prevalent in patients with rotator cuff tears, suggesting its role as a potential risk factor. Vitamin D deficiency has been associated with decreased preoperative shoulder strength as well as increased re-tear rates, postoperative stiffness, and the need for revision surgery in patients who underwent rotator cuff repair. Studies have also demonstrated a potential association between vitamin D deficiency and increased risk of revision after total shoulder arthroplasty. Further research is necessary to elucidate the direct role of vitamin D in the pathogenesis of rotator cuff tears and its impact on clinical outcomes after rotator cuff surgery and total shoulder arthroplasty.
维生素D缺乏在普通人群中非常普遍，并且与各种慢性健康状况相关。除了在骨矿化中的作用外，维生素D还具有多种生理效应，可能会影响肩部疾病的发病机制。维生素D缺乏也可能影响肩部手术后的结果，如肩袖修复和全肩关节置换术。维生素D在组织愈合、骨骼生长以及骨骼肌细胞内稳态的维持中发挥作用。维生素D还具有抗炎作用，这对肩袖健康很重要。维生素D缺乏在肩袖撕裂患者中非常普遍，提示其作为潜在危险因素的作用。维生素D缺乏与术前肩部力量下降以及肩袖修复患者的再撕裂率增加、术后僵硬和翻修手术需求增加有关。研究还表明维生素D缺乏与全肩关节置换术后翻修风险增加之间可能存在关联。有必要进行进一步研究以阐明维生素D在肩袖撕裂发病机制中的直接作用及其对肩袖手术和全肩关节置换术后临床结果的影响。
