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活体肾供体候选人在评估过程中的流程:加拿大安大略省的单中心经验

The Flow of Living Kidney Donor Candidates Through the Evaluation Process: A Single-Center Experience in Ontario, Canada.

作者信息

Habbous Steven, Montesi Beth, Masse Christy, Weernink Corinne, Sarma Sisira, Begen Mehmet A, Lam Ngan N, Dipchand Christine, Yohanna Seychelle, Connaughton Dervla M, Barnieh Lianne, Garg Amit X

机构信息

Department of Epidemiology & Biostatistics, Western University, London, ON, Canada.

Multi-Organ Transplant Program, University Hospital, London, ON, Canada.

出版信息

Can J Kidney Health Dis. 2025 Mar 31;12:20543581251323964. doi: 10.1177/20543581251323964. eCollection 2025.

Abstract

INTRODUCTION

Tracking the evaluation process of living kidney donor candidates facilitates benchmarking and can inform process redesign to improve experiences with the evaluation and enable more living donor kidney transplantation.

METHODS

We reviewed the medical records for all living donor candidates who were actively undergoing evaluation at any time between January 1, 2013, and December 31, 2016, at the London Health Sciences Centre in London, Ontario, Canada. We abstracted information on demographic factors, the evaluation process, reasons for a delayed evaluation, reasons for an evaluation termination (eg, donation, decline, withdrawal, loss to follow-up), frequency and timing of evaluation testing, and recipient dialysis status.

RESULTS

Over time, the number of living donor kidney transplants increased from 22 in 2013 to 32 in 2016 (18% and 34% of which were pre-emptive, respectively). The median number of candidates coming forward doubled from 167 in 2013 (2 candidates per recipient) to 348 in 2016 (4 candidates per recipient). Median time from first contact until donation decreased from 12.8 months in 2013 to 7.1 months in 2016 (a 45% reduction). The time from computed tomography (CT) angiography until donation (n = 74) was a median of 75 (interquartile range [IQR] = 36, 180) days, the longest single step in the evaluation. Common reasons for delay included waiting for the referral of their intended recipient for transplant evaluation (11% of candidates) and a need for the donor candidate to lose weight (8% of candidates). Donors completed the main evaluation tests on a median of 5 different dates. Thirty-six recipients started dialysis after their living donor candidates' evaluation had been underway for at least 3 months.

CONCLUSION

Tracking the steps and reasons for an inefficient living kidney donor evaluation process can be used for quality improvement, and efficiency improvements are expected to translate into improved outcomes and experiences.

摘要

引言

追踪活体肾供体候选人的评估过程有助于建立基准,并可为流程重新设计提供依据,以改善评估体验并促成更多的活体供肾移植。

方法

我们回顾了2013年1月1日至2016年12月31日期间在加拿大安大略省伦敦市伦敦健康科学中心任何时间积极接受评估的所有活体供体候选人的病历。我们提取了有关人口统计学因素、评估过程、评估延迟的原因、评估终止的原因(如捐赠、拒绝、退出、失访)、评估测试的频率和时间,以及受者透析状态的信息。

结果

随着时间的推移,活体供肾移植的数量从2013年的22例增加到2016年的32例(其中分别有18%和34%为抢先移植)。前来评估的候选人中位数从2013年的167例(每位受者2名候选人)增加了一倍,达到2016年的348例(每位受者4名候选人)。从首次接触到捐赠的中位时间从2013年的12.8个月降至2016年的7.1个月(减少了45%)。从计算机断层扫描(CT)血管造影到捐赠的时间(n = 74)中位数为75天(四分位间距[IQR] = 36, 180),这是评估中最长的单个步骤。延迟的常见原因包括等待其意向受者转诊进行移植评估(11%的候选人)以及供体候选人需要减重(8%的候选人)。供体在中位数为5个不同日期完成了主要评估测试。36名受者在其活体供体候选人的评估开始至少3个月后开始透析。

结论

追踪低效的活体肾供体评估过程的步骤和原因可用于质量改进,并且效率的提高有望转化为更好的结果和体验。

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