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寻常型天疱疮与嗜酸性粒细胞性食管炎罕见并存：两例报告

Rare Coexistence of Pemphigus Vulgaris and Eosinophilic Esophagitis: A Report of Two Cases.

作者信息

Khodeir Joe, Ohanian Paul, Saleh Sarah, Karam Karam, Dib Emanuel-Youssef, Chebbo Houssein, Fiani Elias

机构信息

Department of Dermatology Saint Georges Hospital University Medical Center, University of Balamand Beirut Lebanon.

Department of Family Medicine University of Balamand Beirut Lebanon.

出版信息

Clin Case Rep. 2025 Apr 1;13(4):e70388. doi: 10.1002/ccr3.70388. eCollection 2025 Apr.

DOI:10.1002/ccr3.70388
PMID:40171015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11959298/
Abstract

Dysphagia in pemphigus vulgaris (PV) patients should not be attributed solely to PV. Eosinophilic esophagitis (EoE) can coexist and requires endoscopic evaluation and biopsy for accurate diagnosis. Both conditions may share underlying immune mechanisms, emphasizing the importance of precise diagnosis and targeted treatment.

摘要

寻常型天疱疮（PV）患者的吞咽困难不应仅归因于PV。嗜酸性粒细胞性食管炎（EoE）可能并存，需要进行内镜评估和活检以准确诊断。这两种情况可能具有共同的潜在免疫机制，强调了精确诊断和靶向治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f94/11959298/2f5c4f743741/CCR3-13-e70388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f94/11959298/6e60ffdc6253/CCR3-13-e70388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f94/11959298/d100076c9ae0/CCR3-13-e70388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f94/11959298/2f5c4f743741/CCR3-13-e70388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f94/11959298/6e60ffdc6253/CCR3-13-e70388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f94/11959298/d100076c9ae0/CCR3-13-e70388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f94/11959298/2f5c4f743741/CCR3-13-e70388-g001.jpg

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JAAD Case Rep. 2023 Sep 30;42:12-15. doi: 10.1016/j.jdcr.2023.09.018. eCollection 2023 Dec.
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EoE behaves as a unique Th2 disease: a narrative review.嗜酸性食管炎表现为一种独特的2型炎症性疾病：一篇叙述性综述。
Transl Gastroenterol Hepatol. 2023 Jan 25;8:11. doi: 10.21037/tgh-22-15. eCollection 2023.
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Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.度普利尤单抗在成人和青少年嗜酸性食管炎中的应用。
N Engl J Med. 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982.
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Dupilumab monotherapy suppresses recalcitrant pemphigus vulgaris.度普利尤单抗单药疗法可抑制顽固性寻常型天疱疮。
JAAD Case Rep. 2022 Nov 5;31:16-18. doi: 10.1016/j.jdcr.2022.10.035. eCollection 2023 Jan.
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Eosinophilic Esophagitis: A Review.嗜酸性粒细胞性食管炎：综述。
JAMA. 2021 Oct 5;326(13):1310-1318. doi: 10.1001/jama.2021.14920.
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Esophageal Pemphigus Vulgaris: A Rare Etiology of Upper Gastrointestinal Hemorrhage.寻常型天疱疮累及食管：上消化道出血的罕见病因。
Case Rep Gastrointest Med. 2021 Mar 18;2021:5555961. doi: 10.1155/2021/5555961. eCollection 2021.
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The role of T cells in pemphigus vulgaris and bullous pemphigoid.T 细胞在寻常型天疱疮和大疱性类天疱疮中的作用。
Autoimmun Rev. 2020 Nov;19(11):102661. doi: 10.1016/j.autrev.2020.102661. Epub 2020 Sep 14.
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