Plenn Eion, Long Calista, Acri Samantha, Richardson Cheryl
Penn State College of Medicine Hershey Pennsylvania USA.
Psychiatr Res Clin Pract. 2024 Oct 11;7(1):25-31. doi: 10.1176/appi.prcp.20240050. eCollection 2025 Spring.
Antipsychotic prescribing practices in people with intellectual disabilities (ID) have sparked growing concerns about appropriateness and potential risks. The connection between living situations and antipsychotic prescribing practices in this population is a crucial but underexplored area. This study aims to investigate the association between living situation and antipsychotic prescriptions among people with ID.
This retrospective chart review included 112 adults with ID who received care from 2019 to 2021. The investigation examined participants' living situations and assessed antipsychotic prescription rates, antipsychotic class, the presence of a corresponding mental health diagnoses, and polypharmacy. Statistical analyses included univariate and multivariate tests to assess the relationship between living situations and antipsychotic prescriptions, controlling for relevant covariates.
Univariate analysis revealed a significant association between living situation and antipsychotic prescriptions ( < 0.05), with patients in non-familial support homes and group homes more likely to receive antipsychotics. However, multivariate analysis did not confirm this association after adjusting for other variables. Male gender (OR = 4.207, 95% confidence interval (CI) 1.721-10.286) and total medication count (OR = 1.101, 95% CI 1.038-1.169) emerged as significant predictors of antipsychotic prescriptions.
These findings highlight the complexity of antipsychotic prescribing practices among people with ID. While living situation initially appeared to influence prescription patterns, multivariate analysis suggests the importance of considering other factors. Gender and medication count emerge as significant predictors, underscoring the need for tailored interventions and closer monitoring in this population.
智力残疾（ID）患者的抗精神病药物处方行为引发了人们对其合理性和潜在风险的日益关注。该人群的生活状况与抗精神病药物处方行为之间的联系是一个关键但未得到充分探索的领域。本研究旨在调查ID患者的生活状况与抗精神病药物处方之间的关联。
这项回顾性病历审查纳入了112名在2019年至2021年期间接受治疗的成年ID患者。调查考察了参与者的生活状况，并评估了抗精神病药物处方率、抗精神病药物类别、相应心理健康诊断的存在情况以及联合用药情况。统计分析包括单变量和多变量检验，以评估生活状况与抗精神病药物处方之间的关系，并对相关协变量进行控制。
单变量分析显示生活状况与抗精神病药物处方之间存在显著关联（<0.05），非家庭支持性住所和集体住所的患者更有可能接受抗精神病药物治疗。然而，在对其他变量进行调整后，多变量分析并未证实这种关联。男性（优势比[OR]=4.207，95%置信区间[CI]1.721-10.286）和药物总数（OR=1.101，95%CI1.038-1.169）成为抗精神病药物处方的显著预测因素。
这些发现凸显了ID患者抗精神病药物处方行为的复杂性。虽然生活状况最初似乎会影响处方模式，但多变量分析表明考虑其他因素的重要性。性别和药物数量成为显著的预测因素，强调了对该人群进行针对性干预和密切监测的必要性。
