Khan Ceemal, Zahid Nida, Arif Fizzah, Hafiz Asim, Shaikh Omair, Rahman Mohammad Fazlur
Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan.
Department of Oncology, The Aga Khan University Hospital, Karachi, Pakistan.
Scars Burn Heal. 2025 Mar 31;11:20595131251321766. doi: 10.1177/20595131251321766. eCollection 2025 Jan-Dec.
Keloids are elevated, painful scars that extend beyond the original wound's boundaries and can cause significant emotional distress for patients. While combining surgical excision with radiation therapy has shown potential in treating these scars, its effectiveness in local populations remains unclear.
The study was conducted from January 2015 to December 2019 in the Plastic Surgery Department at a tertiary care hospital in Karachi, Pakistan. Twenty-five patients who were treated at the hospital were recruited, while 17 out of 25 fulfilling the inclusion criteria were selected. Patients were treated according to a defined treatment protocol and evaluated after a 2-year follow-up. A survey questionnaire was administered after obtaining consent from the patients via telephonic interviews at a 2-year follow-up.
Out of 25 patients, 17 (68%) met eligibility criteria, eight (32%) were excluded due to lack of follow-up. The patients that presented with keloids, were seven (41%) males and 10 (59%) females. Six (35%) had a family history of keloids. Etiological factors included injury/trauma (n=9, 53%), spontaneous growth (n=6, 35%), and wound site growth (n=2, 12%). Recurrence post-surgery and radiation therapy occurred in 11 (65%) cases, while seven (35%) remained recurrence-free over 24 months. Recurrence frequency was noted in six (55%) patients within six months, three (27%) within 12 months, and two (18%) within 24 months.
Keloid management is a complex field requiring ongoing research to optimize treatment strategies, reduce recurrence rates, and improve patient outcomes through evidence-based protocols in the Pakistani population.
In a recent study conducted at a tertiary care hospital in Karachi, Pakistan researchers investigated the frequency of keloid recurrence following surgical removal and radiation therapy over a period of two years.Keloids are a type of raised scar that can form after an injury or surgery, often causing discomfort and aesthetic concerns for patients.The study aimed to understand how often keloids come back after treatment, particularly when surgery and radiation therapy are combined. This approach is commonly used to manage keloids, but its effectiveness in preventing recurrence over the long term is not fully understood.Over the two-year follow-up period, the researchers tracked a group of patients who had undergone surgical excision (removal) of their keloids followed by radiation therapy. They observed how many of these patients experienced the return of keloids at the site of the original scar.By analyzing the data, the researchers were able to determine the frequency of keloid recurrence in this specific group of patients. This information is important for healthcare providers and patients considering treatment options for keloids, as it helps to better understand the potential outcomes and risks associated with surgical excision and radiation therapy.Overall, the study provides valuable insights into the management of keloids and contributes to our understanding of the long-term effectiveness of combined surgical and radiation therapy in reducing the recurrence of these troublesome scars.
瘢痕疙瘩是高于皮肤表面的、疼痛性瘢痕，其超出了原始伤口的边界，会给患者造成极大的情绪困扰。虽然手术切除联合放射治疗在治疗这些瘢痕方面已显示出潜力，但其在当地人群中的有效性仍不明确。
该研究于2015年1月至2019年12月在巴基斯坦卡拉奇一家三级护理医院的整形外科进行。招募了在该医院接受治疗的25名患者，其中25名中符合纳入标准的17名被选中。患者按照既定的治疗方案进行治疗，并在2年随访后进行评估。在2年随访时通过电话访谈获得患者同意后进行问卷调查。
25名患者中，17名（68%）符合入选标准，8名（32%）因缺乏随访而被排除。出现瘢痕疙瘩的患者中，男性7名（41%），女性10名（59%）。6名（35%）有瘢痕疙瘩家族史。病因包括损伤/创伤（n = 9，53%）、自发生长（n = 6，35%）和伤口部位生长（n = 2，12%）。手术和放射治疗后复发发生在11例（65%），而7例（35%）在24个月内无复发。复发频率在6个月内见于6名（55%）患者，12个月内见于3名（27%）患者，24个月内见于2名（18%）患者。
瘢痕疙瘩的管理是一个复杂的领域，需要持续研究以优化治疗策略、降低复发率，并通过基于循证方案改善巴基斯坦人群的患者治疗效果。
在巴基斯坦卡拉奇一家三级护理医院最近进行的一项研究中，研究人员调查了手术切除和放射治疗后两年内瘢痕疙瘩复发的频率。瘢痕疙瘩是一种在受伤或手术后可能形成的凸起瘢痕，常常给患者带来不适和美观问题。该研究旨在了解瘢痕疙瘩治疗后复发的频率，特别是手术和放射治疗联合使用时。这种方法常用于管理瘢痕疙瘩，但其长期预防复发的有效性尚未完全了解。在两年的随访期内，研究人员跟踪了一组接受瘢痕疙瘩手术切除后再进行放射治疗的患者。他们观察了这些患者中有多少人在原瘢痕部位出现瘢痕疙瘩复发。通过分析数据，研究人员能够确定这一特定患者群体中瘢痕疙瘩复发的频率。这些信息对于考虑瘢痕疙瘩治疗方案的医疗服务提供者和患者很重要，因为它有助于更好地了解与手术切除和放射治疗相关的潜在结果和风险。总体而言，该研究为瘢痕疙瘩的管理提供了有价值的见解，并有助于我们了解手术和放射治疗联合使用在减少这些麻烦瘢痕复发方面的长期有效性。
