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解决“残余充血”问题以改善急性心力衰竭失代偿后的预后。

Addressing 'Residual Congestion' to Improve Prognosis After Acute Heart Failure Decompensation.

作者信息

Gąsecka Aleksandra, Siniarski Aleksander

机构信息

Department of Cardiology, Medical University of Warsaw Warsaw, Poland.

Department of Coronary Artery Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical College Kraków, Poland.

出版信息

Card Fail Rev. 2025 Mar 24;11:e06. doi: 10.15420/cfr.2024.24. eCollection 2025.

Abstract

Congestion is the hallmark and the main therapeutic target in patients with decompensated heart failure (HF). Residual clinical congestion is defined as a high left ventricular diastolic pressure associated with signs and symptoms of HF, such as dyspnoea, rales and oedema, persisting despite guideline-directed medical treatment. Residual congestion in the predischarge and early post-discharge phase is the major risk factor for HF readmission and mortality. Therefore, prompt recognition of congestion and rapid optimisation of medical and device therapy are crucial to induce remission in this malignant process. In this paper we discuss the definitions, prevalence and prognosis of HF decompensation; the significance of assessing residual congestion in HF patients; the results of observational and randomised clinical trials to detect and treat residual congestion; and the current guidelines to prevent recurrent HF decompensation in the context of residual congestion. Strategies to detect and address residual congestion are crucial to stopping readmissions after an acute HF hospitalisation and improving long-term prognosis.

摘要

充血是失代偿性心力衰竭(HF)患者的标志及主要治疗靶点。残余临床充血定义为尽管接受了指南指导的药物治疗,但仍存在与HF体征和症状(如呼吸困难、啰音和水肿)相关的高左心室舒张压。出院前和出院后早期的残余充血是HF再入院和死亡的主要危险因素。因此,迅速识别充血并快速优化药物和器械治疗对于在这一恶性过程中诱导病情缓解至关重要。在本文中,我们讨论了HF失代偿的定义、患病率和预后;评估HF患者残余充血的意义;检测和治疗残余充血的观察性和随机临床试验结果;以及在残余充血背景下预防HF反复失代偿的现行指南。检测和处理残余充血的策略对于阻止急性HF住院后的再入院及改善长期预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0d/11959577/747eecab065e/cfr-11-e06-g001.jpg

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本文引用的文献

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Patient Selection and End Point Definitions for Decongestion Studies in Acute Decompensated Heart Failure: Part 1.
J Soc Cardiovasc Angiogr Interv. 2023 Aug 8;2(6Part B):101060. doi: 10.1016/j.jscai.2023.101060. eCollection 2023 Nov-Dec.
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