Liang Qianqian, Bai Shuomeng, Tan Yushi, Zhang Hong-Yu, Zhang Yuecheng, Zhao Jiquan
School of Chemical Engineering and Technology, Hebei Provincial Key Lab of Green Chemical Technology & High Efficient Energy Saving, Tianjin Key Laboratory of Chemical Process Safety, Hebei University of Technology, Tianjin 300401, P. R. China.
Org Biomol Chem. 2025 Apr 30;23(17):4161-4165. doi: 10.1039/d5ob00098j.
An efficient and convenient pathway to synthesize diverse 3 or 4-oxo-alkyl substituted 1,2,4-triazine-3,5(2,4)-diones has been reported an atom- and step-economical cross-dehydrogenation coupling strategy with good functional group tolerance and wide substrate scope. The present transformation employs inexpensive manganese salt catalysts and iodobenzene diacetate oxidants at room temperature. The synthetic utility of this pathway is further demonstrated by a gram scale reaction.
