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High-performance liquid chromatographic assay for simultaneous estimation of aminoglutethimide and acetylaminoglutethimide in biological fluids.

作者信息

Adam A M, Bradbrook I D, Rogers H J

出版信息

Cancer Chemother Pharmacol. 1985;15(2):176-8. doi: 10.1007/BF00257533.

DOI:10.1007/BF00257533
PMID:4017167
Abstract

A simple rapid high-performance liquid chromatographic assay for simultaneous estimation of aminoglutethimide and its acetylated metabolite acetylamidoglutethimide in plasma, saliva, and urine is described. This assay is suitable for pharmacokinetic studies in normal subjects and patients receiving other medication in addition to aminoglutethimide.

摘要

相似文献

1
High-performance liquid chromatographic assay for simultaneous estimation of aminoglutethimide and acetylaminoglutethimide in biological fluids.
Cancer Chemother Pharmacol. 1985;15(2):176-8. doi: 10.1007/BF00257533.
2
Gas--liquid chromatographic assay of aminoglutethimide and a high-performance liquid chromatographic assay for its acetyl metabolite in biological fluids.生物流体中氨鲁米特的气相色谱分析及其乙酰代谢物的高效液相色谱分析。
J Chromatogr. 1984 Apr 13;307(1):129-35. doi: 10.1016/s0378-4347(00)84079-7.
3
Determination of aminoglutethimide and N-acetylaminoglutethimide in human plasma by reversed-phase liquid chromatography.反相液相色谱法测定人血浆中的氨鲁米特和N-乙酰氨鲁米特
Ther Drug Monit. 1984;6(2):221-6. doi: 10.1097/00007691-198406000-00016.
4
Liquid chromatographic separation and measurement of optical isomers of aminoglutethimide and its acetyl metabolite in plasma, saliva, and urine.血浆、唾液和尿液中氨鲁米特及其乙酰代谢物光学异构体的液相色谱分离与测定。
Ther Drug Monit. 1995 Oct;17(5):538-43. doi: 10.1097/00007691-199510000-00017.
5
High-performance liquid chromatographic assay for aminoglutethimide and its acetylated metabolite in urine.尿液中氨鲁米特及其乙酰化代谢物的高效液相色谱测定法。
J Chromatogr. 1984 Aug 10;309(2):431-5. doi: 10.1016/0378-4347(84)80055-9.
6
Determination of aminoglutethimide and N-acetylaminoglutethimide in human plasma by high-performance liquid chromatography.高效液相色谱法测定人血浆中氨鲁米特和N-乙酰氨鲁米特的含量
J Chromatogr. 1984 Oct 12;310(2):431-7. doi: 10.1016/0378-4347(84)80112-7.
7
Metabolism of aminoglutethimide in humans: identification of hydroxylaminoglutethimide as an induced metabolite.
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8
Single dose pharmacokinetics of aminoglutethimide by a rapid SIM methodology.采用快速SIM方法研究氨鲁米特的单剂量药代动力学。
Int J Clin Pharmacol Ther Toxicol. 1988 Aug;26(8):380-4.
9
Direct enantiomeric high performance liquid chromatographic separation of aminoglutethimide and its major metabolite on a series of Chiralcel OD and Chiralcel OJ columns and its application to biological fluids.
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10
Direct liquid chromatographic resolution of racemic aminoglutethimide and its acetylated metabolite using a chiral alpha 1-acid glycoprotein column.使用手性α1-酸性糖蛋白柱对消旋氨鲁米特及其乙酰化代谢物进行直接液相色谱拆分。
J Chromatogr Sci. 1988 Dec;26(12):616-9. doi: 10.1093/chromsci/26.12.616.

引用本文的文献

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Clinical pharmacokinetics of aromatase inhibitors and inactivators.芳香化酶抑制剂和灭活剂的临床药代动力学
Clin Pharmacokinet. 2003;42(7):619-31. doi: 10.2165/00003088-200342070-00002.
2
Clinical pharmacology of aminoglutethimide in patients with metastatic breast cancer.氨鲁米特在转移性乳腺癌患者中的临床药理学
Cancer Chemother Pharmacol. 1987;20(4):337-41. doi: 10.1007/BF00262588.
3
Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer.氨鲁米特作为乳腺癌内分泌治疗的作用机制

本文引用的文献

1
Polymorphically acetylated aminoglutethimide in humans.人体内多态性乙酰化的氨鲁米特
Br J Cancer. 1982 Sep;46(3):340-5. doi: 10.1038/bjc.1982.209.
2
In vivo and in vitro pharmacological studies of aminoglutethimide as an aromatase inhibitor.氨鲁米特作为一种芳香化酶抑制剂的体内和体外药理学研究。
Cancer Res. 1982 Aug;42(8 Suppl):3353s-3359s.
3
Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma.氨鲁米特治疗绝经后晚期乳腺癌妇女。
Drugs. 1988 Jun;35(6):685-710. doi: 10.2165/00003495-198835060-00005.
4
Clinical pharmacokinetics of endocrine agents used in advanced breast cancer.晚期乳腺癌中使用的内分泌药物的临床药代动力学
Clin Pharmacokinet. 1992 May;22(5):327-58. doi: 10.2165/00003088-199222050-00002.
Ann Intern Med. 1982 Jan;96(1):94-101. doi: 10.7326/0003-4819-96-1-94.
4
Aminoglutethimide bioavailability, pharmacokinetics, and binding to blood constituents.氨鲁米特的生物利用度、药代动力学及与血液成分的结合
J Pharm Sci. 1981 Sep;70(9):1040-3. doi: 10.1002/jps.2600700919.
5
Aminoglutethimide (Elipten-Ciba) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial.氨鲁米特（依立替康-汽巴）作为肾上腺类固醇生成抑制剂：作用机制及治疗试验
J Clin Endocrinol Metab. 1967 Sep;27(9):1239-48. doi: 10.1210/jcem-27-9-1239.
6
Effects of amino-glutethimide on adrenal function in man.
J Clin Endocrinol Metab. 1967 Apr;27(4):481-90. doi: 10.1210/jcem-27-4-481.
7
Serum aminoglutethimide levels: studies of serum half-life, clearance, and patient compliance.血清氨鲁米特水平：血清半衰期、清除率及患者依从性研究
J Clin Pharmacol. 1979 Nov-Dec;19(11-12):704-11. doi: 10.1002/j.1552-4604.1979.tb01640.x.