Liu Xiaohao, Shi Fengxiang, Zeng Jiawei, Bi Jiaming, Mo Chuzi, Chai Yan, Wu Buling, Xu Shuaimei
Department of Periodontics, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Clin Microbiol Rev. 2025 Jun 12;38(2):e0015024. doi: 10.1128/cmr.00150-24. Epub 2025 Apr 2.
SUMMARYThe oral microbiota, characterized by its complexity and density, is increasingly recognized for its significant association with respiratory diseases and their pathogenesis. Changes in the oral microbiome, including shifts in the relative abundance of certain harmful microbes, their byproducts, and virulence elements, have been linked to respiratory disease development and progression. The use of oral microbiome indicators and treatments is essential for the detection, prognosis, and management of respiratory illnesses, providing significant practical benefits. Hence, a thorough understanding of the correlation between oral microbiota and respiratory illnesses is imperative for generating novel therapeutic approaches rooted in the oral microbiota to address these ailments. This review summarizes how oral microbiota are connected to respiratory diseases, explores the mechanisms of their influence, and discusses treatment approaches.
摘要
口腔微生物群以其复杂性和密度为特征,因其与呼吸道疾病及其发病机制的显著关联而日益受到认可。口腔微生物组的变化,包括某些有害微生物、其副产品和毒力因子相对丰度的改变,已与呼吸道疾病的发生和发展相关联。使用口腔微生物组指标和治疗方法对于呼吸道疾病的检测、预后和管理至关重要,具有显著的实际益处。因此,深入了解口腔微生物群与呼吸道疾病之间的相关性对于开发基于口腔微生物群的新型治疗方法以解决这些疾病至关重要。本综述总结了口腔微生物群与呼吸道疾病的联系,探讨了其影响机制,并讨论了治疗方法。