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口腔微生物群与呼吸道疾病:进展与展望

Oral microbiota and respiratory diseases: advances and perspectives.

作者信息

Liu Xiaohao, Shi Fengxiang, Zeng Jiawei, Bi Jiaming, Mo Chuzi, Chai Yan, Wu Buling, Xu Shuaimei

机构信息

Department of Periodontics, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong, China.

Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.

出版信息

Clin Microbiol Rev. 2025 Jun 12;38(2):e0015024. doi: 10.1128/cmr.00150-24. Epub 2025 Apr 2.

Abstract

SUMMARYThe oral microbiota, characterized by its complexity and density, is increasingly recognized for its significant association with respiratory diseases and their pathogenesis. Changes in the oral microbiome, including shifts in the relative abundance of certain harmful microbes, their byproducts, and virulence elements, have been linked to respiratory disease development and progression. The use of oral microbiome indicators and treatments is essential for the detection, prognosis, and management of respiratory illnesses, providing significant practical benefits. Hence, a thorough understanding of the correlation between oral microbiota and respiratory illnesses is imperative for generating novel therapeutic approaches rooted in the oral microbiota to address these ailments. This review summarizes how oral microbiota are connected to respiratory diseases, explores the mechanisms of their influence, and discusses treatment approaches.

摘要

摘要

口腔微生物群以其复杂性和密度为特征,因其与呼吸道疾病及其发病机制的显著关联而日益受到认可。口腔微生物组的变化,包括某些有害微生物、其副产品和毒力因子相对丰度的改变,已与呼吸道疾病的发生和发展相关联。使用口腔微生物组指标和治疗方法对于呼吸道疾病的检测、预后和管理至关重要,具有显著的实际益处。因此,深入了解口腔微生物群与呼吸道疾病之间的相关性对于开发基于口腔微生物群的新型治疗方法以解决这些疾病至关重要。本综述总结了口腔微生物群与呼吸道疾病的联系,探讨了其影响机制,并讨论了治疗方法。

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Oral microbiota and respiratory diseases: advances and perspectives.口腔微生物群与呼吸道疾病:进展与展望
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本文引用的文献

1
Epidemiological associations between periodontitis and cancer.牙周炎与癌症的流行病学关联。
Periodontol 2000. 2024 Oct;96(1):74-82. doi: 10.1111/prd.12599. Epub 2024 Sep 20.
2
Inhibition of SARS-CoV-2 infection by and the oral microbiome.抑制 SARS-CoV-2 感染的 和口腔微生物组。
Microbiol Spectr. 2024 Oct 3;12(10):e0059924. doi: 10.1128/spectrum.00599-24. Epub 2024 Aug 20.
3
The oral-gut microbiome axis in health and disease.口腔-肠道微生物轴在健康和疾病中的作用。
Nat Rev Microbiol. 2024 Dec;22(12):791-805. doi: 10.1038/s41579-024-01075-5. Epub 2024 Jul 22.

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