Department of Oral Medicine, Birmingham Dental Hospital and School of Dentistry, Birmingham, UK.
Department of Oral Biology, School of Dental Medicine University at Buffalo, Buffalo, New York, USA.
Periodontol 2000. 2024 Oct;96(1):74-82. doi: 10.1111/prd.12599. Epub 2024 Sep 20.
There is a postulated association of periodontitis with a number of human cancers. This narrative review provides current epidemiological evidence on the association between periodontitis and cancer. A PubMed search with the relevant keywords (periodontal disease, periodontitis, cancer, and malignancy) was completed to identify relevent articles. We present a narrative review on the association between periodontal disease and a range of cancers, including oral cancer, stomach and esophageal cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, hematological malignancies, liver cancer, breast cancer, and ovarian cancer. While there is a considerable body of epidemiological evidence that supports the association between periodontal disease and cancer, this is largely from cohort and case-control studies and the association may therefore be circumstantial as little evidence exists in the form of treatment trials that would validate the role of periodontal disease in the process of cancer initiation and development.
有一种假设认为，牙周炎与多种人类癌症有关。本综述性研究提供了目前关于牙周炎与癌症之间关联的流行病学证据。通过使用相关关键词（牙周病、牙周炎、癌症和恶性肿瘤）在 PubMed 上进行了检索，以确定相关文章。我们对牙周病与一系列癌症（包括口腔癌、胃癌和食管癌、结直肠癌、肺癌、胰腺癌、前列腺癌、血液恶性肿瘤、肝癌、乳腺癌和卵巢癌）之间的关联进行了叙述性综述。虽然有相当多的流行病学证据支持牙周病与癌症之间的关联，但这主要来自队列研究和病例对照研究，因此这种关联可能只是一种推测，因为几乎没有以治疗试验的形式存在的证据可以证实牙周病在癌症发生和发展过程中的作用。
