Lederer Ann-Kathrin, Musholt Thomas J
Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstraße 1, 55131, Mainz, Deutschland.
Chirurgie (Heidelb). 2025 Apr 2. doi: 10.1007/s00104-025-02275-2.
Papillary thyroid cancer (PTC) is the most frequent malignant thyroid tumor in Germany. The diagnosis can only be confirmed by histological examination of the suspicious tissue. The clinical signs, sonographic findings, and the results of fine-needle aspiration, possibly supplemented by subsequent molecular genetic analysis, can confirm the suspected diagnosis before surgery. The prognosis is very good if the diagnosis is made early and, depending on the size of the tumor, complete surgical removal is achieved, with a 10-year survival rate of more than 90%; however, histologically PTC has several variants that are associated with either a high or low risk of metastases and recurrence in patients. Therefore, the extent of necessary treatment, in particular surgical interventions for PTC has been discussed for years. This article provides an overview of the current knowledge on the diagnosis, treatment and prognosis of PTC.
甲状腺乳头状癌(PTC)是德国最常见的甲状腺恶性肿瘤。只有通过对可疑组织进行组织学检查才能确诊。临床体征、超声检查结果以及细针穿刺结果,可能还需后续分子遗传学分析辅助,能够在手术前确诊疑似病例。如果早期诊断且根据肿瘤大小实现完整手术切除,预后非常好,10年生存率超过90%;然而,从组织学角度来看,PTC有几种变体,与患者转移和复发的高风险或低风险相关。因此,多年来一直在讨论PTC必要治疗的范围,尤其是手术干预措施。本文概述了目前关于PTC诊断、治疗和预后的知识。