Krzesinski J M, Godon J P, Rorive G L
Clin Exp Hypertens A. 1985;7(5-6):721-33. doi: 10.3109/10641968509077223.
The effect of salt and/or volume depletion has been tested in 6 end-stage renal disease and 11 essential hypertensive patients (HTA) on red blood cell (RBC) ionic fluxes. Volume depletion promotes an increase in the RBC Na-K ATPase activity with, as a result, a significant decrease in intracellular sodium concentration [Na)ic). Moreover, a factor has been found in the plasma of uremic subjects which causes natriuresis when injected in rat renal arteries. The concentration of this factor decreases during dialysis in relation to the weight loss and the increase in the RBC Na-K pump activity. In essential hypertension, the effect of a low salt diet on the blood pressure is correlated with the improvement of RBC Na-K ATPase activity. These experiments illustrate the presence of a Na-K ATPase inhibitor in the plasma of these subjects, dependent on sodium and water balance.
在6名终末期肾病患者和11名原发性高血压患者中，检测了盐和/或容量缺失对红细胞离子通量的影响。容量缺失会促进红细胞钠钾ATP酶活性增加，结果细胞内钠浓度（[Na⁺]ic）显著降低。此外，在尿毒症患者血浆中发现一种因子，将其注入大鼠肾动脉时会引起利钠作用。在透析过程中，该因子的浓度随着体重减轻和红细胞钠钾泵活性增加而降低。在原发性高血压中，低盐饮食对血压的影响与红细胞钠钾ATP酶活性的改善相关。这些实验表明，这些受试者血浆中存在一种钠钾ATP酶抑制剂，其依赖于钠和水平衡。
