Groenewegen G, Buurman W A, van der Linden C J
Clin Immunol Immunopathol. 1985 Sep;36(3):378-85. doi: 10.1016/0090-1229(85)90058-3.
The influence of lymphokines, the soluble mediators produced by lymphocytes, on the morphology and the motility of endothelial cells in vitro is described. Lymphokines induced an altered morphology and an increased motility of canine and human venous endothelial cells. The action of the lymphokines was species specific. The data are discussed in relation to in vitro and in vivo data on the behavior of endothelial cells in inflammation. The in vitro experiments allow further study of the role of endothelial cells in inflammatory and immunological processes.
本文描述了淋巴细胞产生的可溶性介质——淋巴因子对体外培养的内皮细胞形态和运动性的影响。淋巴因子可诱导犬类和人类静脉内皮细胞形态改变并增加其运动性。淋巴因子的作用具有种属特异性。结合内皮细胞在炎症中行为的体外和体内数据对这些结果进行了讨论。体外实验有助于进一步研究内皮细胞在炎症和免疫过程中的作用。
