Cohen M C, Picciano P T, Douglas W J, Yoshida T, Kreutzer D L, Cohen S
Science. 1982 Jan 15;215(4530):301-3. doi: 10.1126/science.6797069.
Many of the reactions of cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category of lymphokine action involves effects on cell motility. These effects have been described mainly with respect to inflammatory cells. In this report, we describe the ability of a lymphocyte product to inhibit the migration of endothelial cells in a system in vitro. The responsible factor is distinct from a previously described mediator that inhibits the migration of tumor cells. The ability of lymphocytes to influence the migration properties of endothelial cells is consistent with data of others showing a relation between the immune system and processes involving neovascularization.
细胞免疫的许多反应是由可溶性淋巴细胞衍生因子（淋巴因子）介导的。淋巴因子作用的一个重要类别涉及对细胞运动的影响。这些影响主要是针对炎症细胞进行描述的。在本报告中，我们描述了一种淋巴细胞产物在体外系统中抑制内皮细胞迁移的能力。相关因子与先前描述的抑制肿瘤细胞迁移的介质不同。淋巴细胞影响内皮细胞迁移特性的能力与其他研究数据一致，这些数据表明免疫系统与涉及新血管形成的过程之间存在关联。
