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系统性硬化症中肾上腺皮质腺瘤的管理:一例报告。

Management of adrenocortical adenoma in systemic sclerosis: A case report.

作者信息

Luo Zongyan, Shi Yuanlong, Yang Jinye, Duan Yuanpeng, Wang Qiao, Li Can, Yang Sinan, Peng Bo, Zhang Kun, Yang Libo, Zhao Bin, Bi Chengwei

机构信息

Department of Urology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, China.

出版信息

J Int Med Res. 2025 Apr;53(4):3000605251326822. doi: 10.1177/03000605251326822. Epub 2025 Apr 2.

DOI:10.1177/03000605251326822
PMID:40173033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11967233/
Abstract

Systemic sclerosis is a rare autoimmune disorder that affects multiple organ systems, including the lungs, kidneys, and liver, and often leads to fatal complications. Adrenocortical adenoma, a benign tumor, can secrete hormones such as cortisol, resulting in symptoms including hypertension, diabetes, and obesity, although it can also be asymptomatic. This article presents a case of a patient with systemic sclerosis and adrenocortical adenoma, detailing the diagnostic and therapeutic journey before and after laparoscopic adrenal tumor resection. It offers insights into the clinical management of such cases and analyzes how surgical removal of the adenoma affects the treatment and prognosis of systemic sclerosis. This study aimed to provide valuable knowledge to healthcare professionals managing patients with this dual diagnosis, further contributing to the medical understanding of treatment outcomes in such cases.

摘要

系统性硬化症是一种罕见的自身免疫性疾病,会影响包括肺、肾和肝脏在内的多个器官系统,且常常导致致命的并发症。肾上腺皮质腺瘤是一种良性肿瘤,可分泌诸如皮质醇等激素,导致包括高血压、糖尿病和肥胖等症状,不过它也可能没有症状。本文介绍了一例患有系统性硬化症和肾上腺皮质腺瘤的患者病例,详细阐述了腹腔镜肾上腺肿瘤切除术前和术后的诊断及治疗过程。它为这类病例的临床管理提供了见解,并分析了腺瘤的手术切除如何影响系统性硬化症的治疗和预后。本研究旨在为管理患有这种双重诊断的患者的医疗保健专业人员提供有价值的知识,进一步增进医学界对此类病例治疗结果的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/9aa41cbda5a9/10.1177_03000605251326822-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/d9bfa517d7f2/10.1177_03000605251326822-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/a05cdd061016/10.1177_03000605251326822-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/29408baf2553/10.1177_03000605251326822-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/eeff647e8ea7/10.1177_03000605251326822-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/1220ec199162/10.1177_03000605251326822-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/9aa41cbda5a9/10.1177_03000605251326822-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/d9bfa517d7f2/10.1177_03000605251326822-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/a05cdd061016/10.1177_03000605251326822-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/29408baf2553/10.1177_03000605251326822-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/eeff647e8ea7/10.1177_03000605251326822-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/1220ec199162/10.1177_03000605251326822-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ac/11967233/9aa41cbda5a9/10.1177_03000605251326822-fig6.jpg

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本文引用的文献

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Novel Therapeutic Strategies in the Treatment of Systemic Sclerosis.系统性硬化症治疗中的新型治疗策略
Pharmaceuticals (Basel). 2023 Jul 27;16(8):1066. doi: 10.3390/ph16081066.
2
Cutaneous Manifestations, Clinical Characteristics, and Prognosis of Patients With Systemic Sclerosis Sine Scleroderma: Data From the International EUSTAR Database.无皮肤硬化系统性硬皮病患者的皮肤表现、临床特征和预后:来自国际 EUSTAR 数据库的数据。
JAMA Dermatol. 2023 Aug 1;159(8):837-847. doi: 10.1001/jamadermatol.2023.1729.
3
Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment.
用于系统性硬化症治疗的中医整合响应性微针
Research (Wash D C). 2023 May 9;6:0141. doi: 10.34133/research.0141. eCollection 2023.
4
Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic.护理模式与中医体质作为系统性硬化症患者抑郁和焦虑的影响因素:一项在新冠疫情期间的横断面研究
Front Integr Neurosci. 2023 Feb 14;17:1052683. doi: 10.3389/fnint.2023.1052683. eCollection 2023.
5
Current advances in the treatment of systemic sclerosis.系统性硬化症治疗的最新进展。
Curr Opin Pharmacol. 2022 Jun;64:102211. doi: 10.1016/j.coph.2022.102211. Epub 2022 Apr 18.
6
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.《2022 年世界卫生组织肾上腺皮质肿瘤分类概述》。
Endocr Pathol. 2022 Mar;33(1):155-196. doi: 10.1007/s12022-022-09710-8. Epub 2022 Mar 14.
7
Early diagnosis of systemic sclerosis, where do we stand today?系统性硬化症的早期诊断,我们如今处于什么阶段?
Expert Rev Clin Immunol. 2022 Jan;18(1):1-3. doi: 10.1080/1744666X.2022.2015327. Epub 2022 Jan 13.
8
Scleroderma of the Hand: Evaluation and Treatment.手部硬皮病:评估与治疗。
J Am Acad Orthop Surg. 2020 Aug 15;28(16):e686-e695. doi: 10.5435/JAAOS-D-19-00547.
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The systemic sclerosis patient in the COVID-19 era: the challenging crossroad between immunosuppression, differential diagnosis and long-term psychological distress.COVID-19 时代的系统性硬化症患者:免疫抑制、鉴别诊断和长期心理困扰之间的艰难十字路口。
Clin Rheumatol. 2020 Jul;39(7):2043-2047. doi: 10.1007/s10067-020-05193-2. Epub 2020 Jun 8.
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