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大便失禁的负担:从经济负担和与健康相关的生活质量方面评估其对社会的影响。

The Burden of Fecal Incontinence: Evaluating the Societal Impact in Terms of Economic Burden and Health-Related Quality of Life.

作者信息

Assmann Sadé L, Kimman Merel L, Breukink Stéphanie O, Keszthelyi Daniel

机构信息

Department of Surgery and Colorectal Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands.

Department of Gastroenterology-Hepatology, Maastricht University Medical Centre, Maastricht, the Netherlands.

出版信息

Neurogastroenterol Motil. 2025 Sep;37(9):e70036. doi: 10.1111/nmo.70036. Epub 2025 Apr 2.

Abstract

INTRODUCTION

Fecal incontinence (FI) is a chronic condition characterized by the involuntary loss of stool, significantly impacting health-related quality of life (HRQoL) and imposing a substantial economic burden on society.

METHODS

This bottom-up, retrospective, cross-sectional burden of disease study offers a comprehensive cost analysis of FI in a Dutch population sample. Utilizing the iMTA Medical Consumption Questionnaire (MCQ) and the iMTA Productivity Cost Questionnaire (PCQ), we analyzed costs over a 3-month period from a societal perspective, which encompasses healthcare costs, out-of-pocket expenses, and productivity losses. Non-parametric bootstrapping was applied to identify differences in costs between several subgroups of patients. Additionally, we assessed HRQoL using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) questionnaire. Differences in HRQoL between subgroups were determined using the nonparametric Mann-Whitney U test.

RESULTS

Cost and HRQoL data were collected from 80 FI patients aged 39-89 (82.5% female). The mean societal costs were €2424 per patient per quarter, of which €1572 can be contributed to healthcare costs. Notably, unemployed patients incurred significantly higher costs compared to employed and retired patients. No significant difference in costs was seen between subgroups based on gender, age, educational level, or frequency of FI episodes. The mean HRQoL score was 0.72 (SD 0.78). Younger and unemployed patients reported lower HRQoL scores.

CONCLUSION

This study demonstrates that FI negatively impacts HRQoL and has a considerable impact on societal costs, extending beyond direct healthcare expenses. Policymakers, healthcare providers, and employers should take these findings into account when designing management strategies and allocating resources for FI treatment and support.

摘要

引言

大便失禁(FI)是一种慢性病,其特征为粪便不自主排出,对健康相关生活质量(HRQoL)有重大影响,并给社会带来巨大经济负担。

方法

这项自下而上的回顾性横断面疾病负担研究对荷兰人群样本中的FI进行了全面成本分析。我们使用iMTA医疗消费问卷(MCQ)和iMTA生产力成本问卷(PCQ),从社会角度分析了3个月期间的成本,其中包括医疗成本、自付费用和生产力损失。采用非参数自助法来确定几个患者亚组之间的成本差异。此外,我们使用欧洲五维度五水平健康量表(EQ-5D-5L)问卷评估HRQoL。亚组之间HRQoL的差异使用非参数曼-惠特尼U检验确定。

结果

收集了80名年龄在39 - 89岁的FI患者(82.5%为女性)的成本和HRQoL数据。每位患者每季度的平均社会成本为2424欧元,其中1572欧元可归因于医疗成本。值得注意的是,与在职和退休患者相比,失业患者产生的成本显著更高。基于性别、年龄、教育水平或FI发作频率的亚组之间在成本上没有显著差异。HRQoL平均得分为0.72(标准差0.78)。年轻和失业患者报告的HRQoL得分较低。

结论

本研究表明,FI对HRQoL有负面影响,并且对社会成本有相当大的影响,这一影响超出了直接医疗费用。政策制定者、医疗服务提供者和雇主在设计管理策略以及为FI治疗和支持分配资源时应考虑这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/12351359/efc68ccd6819/NMO-37-e70036-g001.jpg

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