Battino D, Binelli S, Bossi L, Canger R, Croci D, Cusi C, De Giambattista M, Avanzini G
Clin Pharmacokinet. 1985 May-Jun;10(3):279-84. doi: 10.2165/00003088-198510030-00007.
Plasma concentrations of carbamazepine were monitored in 9 pregnant epileptic patients treated with the drug alone at constant doses during pregnancy and for at least 3 months after delivery. In addition, plasma concentrations of the metabolite, carbamazepine 10,11-epoxide were measured in 6 of the 9 patients. Plasma carbamazepine concentrations were fairly stable during pregnancy, and carbamazepine relative plasma clearances were significantly higher in weeks 4 to 24 than in weeks 25 to 32. After the end of the second trimester, there were no variations in plasma carbamazepine 10,11-epoxide concentrations and carbamazepine 10,11-epoxide:carbamazepine ratios. Both parameters were significantly higher in weeks 4 to 24 than in weeks 25 to 32 of pregnancy.
对9例仅在孕期接受恒定剂量卡马西平治疗且产后至少3个月的妊娠癫痫患者进行了血浆卡马西平浓度监测。此外，对9例患者中的6例测定了代谢物卡马西平10,11 - 环氧化物的血浆浓度。孕期血浆卡马西平浓度相当稳定，第4至24周的卡马西平相对血浆清除率显著高于第25至32周。孕中期结束后，血浆卡马西平10,11 - 环氧化物浓度及卡马西平10,11 - 环氧化物与卡马西平的比值无变化。这两个参数在妊娠第4至24周均显著高于第25至32周。
