Lander C M, Edwards V E, Eadie M J, Tyrer J H
Neurology. 1977 Feb;27(2):128-31. doi: 10.1212/wnl.27.2.128.
Plasma anticonvulsant levels were followed during pregnancy in 11 epileptic women taking phenytoin and/or phenobarbital or a drug metabolized in the body to phenobarbital. As judged from the relationship between plasma level and drug dose, phenytoin requirement increased in all 10 women taking this drug during pregnancy. The requirement fell again in the puerperium. Plasma phenobarbital levels decreased during pregnancy in all five women taking a constant daily dose of phenobarbital or a congener. These findings should be borne in mind if epileptics are to be protected against seizures during pregnancy and against anticonvulsant overdosage during the puerperium.
对11名服用苯妥英钠和/或苯巴比妥或体内可代谢为苯巴比妥的药物的癫痫女性在孕期监测了血浆抗惊厥药水平。根据血浆水平与药物剂量之间的关系判断，所有10名孕期服用该药物的女性对苯妥英钠的需求量增加。产褥期需求量再次下降。所有5名每日服用固定剂量苯巴比妥或同类药物的女性在孕期血浆苯巴比妥水平降低。如果要在孕期保护癫痫患者不发作，并在产褥期防止抗惊厥药过量，就应牢记这些发现。
