Briele H A, Walker M J, Das Gupta T K
Clin Plast Surg. 1985 Jul;12(3):495-504.
Cutaneous melanoma of the head and neck accounts for approximately 20 per cent of all melanomas. Variation in the incidence of melanoma by sex and by subsites within the head and neck is related to exposure to sunlight. Study of the precursor skin lesions of individuals and families at high risk for melanoma are providing new insights into the biology of melanoma. The clinical importance of such information is earlier diagnosis and treatment. With microstaging techniques it has become apparent that in many instances the primary tumor can be excised safely with narrower margins than were thought necessary in the past. The role of elective lymph-node dissection remains controversial, but when it is performed a complete dissection is recommended. Improvement in adjunctive methods of treatment is needed, but significant palliation can be achieved, with occasional long-term survival.
头颈部皮肤黑色素瘤约占所有黑色素瘤的20%。黑色素瘤发病率在头颈部的性别差异及不同亚部位差异与阳光暴露有关。对黑色素瘤高危个体及家族的皮肤前驱病变研究为黑色素瘤生物学提供了新见解。此类信息的临床重要性在于早期诊断和治疗。借助微分期技术已明显看出,在许多情况下,原发肿瘤能够以比过去认为必要的更窄切缘安全切除。选择性淋巴结清扫的作用仍存在争议,但进行该操作时建议彻底清扫。辅助治疗方法需要改进,但可实现显著缓解,偶尔能实现长期生存。