Kristjánsson Ragnar P, Dietz Jojo Biel-Nielsen, Davíðsson Ólafur B, Kjerulff Bertram, Rostgaard Klaus, Dowsett Joseph, Søegaard Signe Holst, Rotbain Emelie Curovic, Schwinn Michael, Burgdorf Kristoffer Sølvsten, Bay Jakob Thaning, Mikkelsen Christina, Ullum Henrik, Brunak Søren, Sørensen Erik, Jensen Bitten Aagaard, Bruun Mie Topholm, Nyegaard Mette, Ostrowski Sisse Rye, Pedersen Ole Birger, Erikstrup Christian, Hansen Thomas Folkmann, Hjalgrim Henrik
Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Sci Rep. 2025 Apr 2;15(1):11312. doi: 10.1038/s41598-025-95276-4.
Infectious mononucleosis (IM), predominantly caused by primary Epstein-Barr virus (EBV) infection, is a common disease in adolescents and young adults. EBV infection is nearly ubiquitous globally. Although primary EBV infection is asymptomatic in most individuals, IM manifests in a subset infected during adolescence or young adulthood. IM occurrence is linked to sibship structure, and is associated with increased risk of multiple sclerosis, other autoimmune diseases, and cancer later in life. We analyzed 47 biomarkers in 5,526 Danish individuals aged 18-60 years, of whom 604 had a history of IM, examining their associations with IM history up to 48 years after IM diagnosis. No significant long-term associations were observed after adjusting for multiple comparisons. When restricting the analysis to individuals measured within 10 years post-IM diagnosis, a statistically significant increase in CRP levels was observed in females. This association was not driven by oral contraceptive use. No significant associations between sibship structure and biomarker levels were detected. In conclusion, our study shows that while IM may lead to a transient increase in CRP levels in females, it does not result in long-term alterations in plasma biomarkers related to immune function, suggesting other mechanisms may be responsible for the long-term health impacts associated with IM.
传染性单核细胞增多症（IM）主要由原发性爱泼斯坦-巴尔病毒（EBV）感染引起，是青少年和青年中的常见疾病。EBV感染在全球几乎普遍存在。虽然大多数个体的原发性EBV感染无症状，但IM在青春期或青年期感染的一部分人中表现出来。IM的发生与同胞结构有关，并与晚年患多发性硬化症、其他自身免疫性疾病和癌症的风险增加有关。我们分析了5526名年龄在18至60岁的丹麦人的47种生物标志物，其中604人有IM病史，研究了它们与IM诊断后长达48年的IM病史之间的关联。在进行多重比较调整后，未观察到显著的长期关联。当将分析限制在IM诊断后10年内测量的个体时，女性的CRP水平出现了统计学上的显著升高。这种关联不是由口服避孕药使用驱动的。未检测到同胞结构与生物标志物水平之间的显著关联。总之，我们的研究表明，虽然IM可能导致女性CRP水平短暂升高，但它不会导致与免疫功能相关的血浆生物标志物的长期改变，这表明其他机制可能是与IM相关的长期健康影响的原因。
