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多灶性结外边缘区淋巴瘤的意外发现。

An unexpected find of multifocal extranodal marginal zone lymphoma.

作者信息

Van den Bosch Glenn, Develter M, Willemse J, Boes J, Somers K, Douven U

机构信息

Department of Laboratory Medicine, General Hospital Turnhout, Turnhout, Belgium.

Clinical Laboratory, AZ Turnhout, Campus St. Elisabeth, Rubensstraat 166, Turnhout, 2300, Belgium.

出版信息

Ann Hematol. 2025 Apr 3. doi: 10.1007/s00277-025-06283-4.

DOI:10.1007/s00277-025-06283-4
PMID:40175605
Abstract

In this case report we describe a patient who was diagnosed with extranodal marginal zone lymphoma (EMZL) at two different body sites, namely at the mucosa of the stomach and the lung. Since the patient presented with a main complaint of dyspnoea, this was a rather unexpected medical finding. To our knowledge, this is even the first case of multifocal EMZL in which the coexistent involvement of the stomach and lung is extensively documented. All medical and technical investigations that were performed during diagnosis and staging are described whilst discussing the typical characteristics of these kinds of lymphomas as stated in current guidelines and literature.

摘要

在本病例报告中,我们描述了一名在两个不同身体部位,即胃黏膜和肺部被诊断为结外边缘区淋巴瘤(EMZL)的患者。由于患者的主要诉求是呼吸困难,这是一个相当意外的医学发现。据我们所知,这甚至是第一例多灶性EMZL病例,其中胃和肺同时受累的情况有广泛记录。在讨论当前指南和文献中所述的这类淋巴瘤的典型特征时,描述了诊断和分期过程中进行的所有医学和技术检查。

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1
An unexpected find of multifocal extranodal marginal zone lymphoma.多灶性结外边缘区淋巴瘤的意外发现。
Ann Hematol. 2025 Apr 3. doi: 10.1007/s00277-025-06283-4.
2
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本文引用的文献

1
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.《世界卫生组织造血与淋巴组织肿瘤分类》第五版:淋巴肿瘤。
Leukemia. 2022 Jul;36(7):1720-1748. doi: 10.1038/s41375-022-01620-2. Epub 2022 Jun 22.
2
The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee.成熟淋巴细胞肿瘤国际共识分类:临床咨询委员会报告。
Blood. 2022 Sep 15;140(11):1229-1253. doi: 10.1182/blood.2022015851.
3
Extranodal Marginal Zone Lymphoma: Pathogenesis, Diagnosis and Treatment.
结外边缘区淋巴瘤:发病机制、诊断与治疗
Cancers (Basel). 2022 Mar 29;14(7):1742. doi: 10.3390/cancers14071742.
4
Primary pulmonary marginal zone lymphoma: an unusual cause of pulmonary infiltrates.原发性肺边缘区淋巴瘤:肺部浸润的罕见病因。
Respirol Case Rep. 2021 Jun 29;9(8):e00806. doi: 10.1002/rcr2.806. eCollection 2021 Aug.
5
Active surveillance of primary extranodal marginal zone lymphoma of bronchus-associated lymphoid tissue.支气管相关淋巴组织原发性结外黏膜边缘区淋巴瘤的主动监测。
Blood Adv. 2021 Jan 26;5(2):345-351. doi: 10.1182/bloodadvances.2020003213.
6
Marginal zone lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.边缘区淋巴瘤:ESMO 诊断、治疗及随访临床实践指南
Ann Oncol. 2020 Jan;31(1):17-29. doi: 10.1016/j.annonc.2019.10.010. Epub 2019 Dec 4.
7
MALT lymphoma: Genetic abnormalities, immunological stimulation and molecular mechanism.黏膜相关淋巴组织淋巴瘤:基因异常、免疫刺激与分子机制
Best Pract Res Clin Haematol. 2017 Mar-Jun;30(1-2):13-23. doi: 10.1016/j.beha.2016.09.002. Epub 2016 Nov 4.
8
Pulmonary mucosa-associated lymphoid tissue lymphoma revisited.重新审视肺黏膜相关淋巴组织淋巴瘤。
Eur Respir J. 2016 Apr;47(4):1244-60. doi: 10.1183/13993003.01701-2015. Epub 2016 Jan 21.
9
Primary Pulmonary Lymphomas.原发性肺淋巴瘤
Adv Anat Pathol. 2015 Nov;22(6):355-75. doi: 10.1097/PAP.0000000000000090.
10
A retrospective international study on primary extranodal marginal zone lymphoma of the lung (BALT lymphoma) on behalf of International Extranodal Lymphoma Study Group (IELSG).一项代表国际结外淋巴瘤研究组(IELSG)开展的关于肺原发性结外边缘区淋巴瘤(BALT淋巴瘤)的回顾性国际研究。
Hematol Oncol. 2016 Dec;34(4):177-183. doi: 10.1002/hon.2243. Epub 2015 Jul 7.