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采用分期联合前后路开放根治性滑膜切除术治疗膝关节弥漫性滑膜软骨瘤病:1例报告

Disseminated synovial chondromatosis of the knee treated by open radical synovectomy using staged combined anterior and posterior approaches: a case report.

作者信息

Zeleke Sileshi Serebe, Nigussie Koyachew Abate, Mesfin Yeab Mulat, Fentie Wodaje Mesele, Stein Michael, Molla Daniel Kassie

机构信息

Department of Orthopedics, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Medical School for International Health, Ben-Gurion University of the Negev, Beer Sheva, Israel.

出版信息

J Med Case Rep. 2025 Apr 2;19(1):152. doi: 10.1186/s13256-025-05087-4.

Abstract

INTRODUCTION

Synovial chondromatosis is a rare, benign condition characterized by the formation of multiple cartilaginous nodules within the synovial membrane of joints. Despite its rarity, there remains significant uncertainty regarding its optimal management. Early diagnosis and appropriate surgical intervention are essential, yet the literature on best practices remains limited. The anterior compartment of the knee is mostly affected, and widespread illness is quite uncommon. In severe cases, the most effective surgical approach for severe cases is still debated. This report presents a rare case of knee synovial chondromatosis with extensive involvement of both anterior and posterior compartments, treated with a staged surgical approach.

CASE PRESENTATION

A 50-year-old Semitic male presented with a 15-year history of progressively worsening right knee pain and swelling. Physical examination revealed significant swelling, restricted range of motion, and a palpable mass in the anterior and posterior knee, prompting further imaging. Magnetic resonance imaging confirmed the presence of large loose bodies and extensive synovial hypertrophy, leading to the decision for surgical intervention. The patient underwent a staged open radical synovectomy, first targeting the anterior compartment followed by the posterior compartment. Two large loose bodies were removed, and histopathology confirmed synovial chondromatosis with synovial papillary hyperplasia. The patient responded well postoperatively, with improved range of motion following physiotherapy.

CONCLUSION

Generalized synovial chondromatosis of the knee is a rare but significant condition that requires early diagnosis and surgical intervention to prevent joint degeneration. A staged anterior and posterior synovectomy provides effective management of the disease with good clinical outcomes and reduced risk of recurrence.

摘要

引言

滑膜软骨瘤病是一种罕见的良性疾病,其特征是在关节滑膜内形成多个软骨结节。尽管其罕见性,但关于其最佳治疗方法仍存在重大不确定性。早期诊断和适当的手术干预至关重要,然而关于最佳实践的文献仍然有限。膝关节前侧间室最常受累,广泛发病相当少见。在严重病例中,针对严重病例的最有效手术方法仍存在争议。本报告介绍了一例罕见的膝关节滑膜软骨瘤病,前后间室均广泛受累,采用分期手术方法进行治疗。

病例报告

一名50岁的闪米特男性,有15年逐渐加重的右膝疼痛和肿胀病史。体格检查发现明显肿胀、活动范围受限,膝关节前后可触及肿块,遂进行进一步影像学检查。磁共振成像证实存在大量游离体和广泛的滑膜增生,决定进行手术干预。患者接受了分期开放性根治性滑膜切除术,首先针对前侧间室,然后是后侧间室。取出了两个大的游离体,组织病理学证实为滑膜软骨瘤病伴滑膜乳头样增生。患者术后反应良好,经物理治疗后活动范围有所改善。

结论

膝关节广泛性滑膜软骨瘤病是一种罕见但严重的疾病,需要早期诊断和手术干预以防止关节退变。分期进行前后滑膜切除术可有效治疗该疾病,临床效果良好,复发风险降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8237/11967116/d51beed3c043/13256_2025_5087_Fig1_HTML.jpg

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