人乳头瘤病毒相关癌症负担的转移：从宫颈癌到口咽癌。
Shifting HPV-cancer burden: from cervical cancer to oropharyngeal cancer.
作者信息
Volpi Connor R, Giuliano Anna R, Morais Edith, Felsher Marisa
机构信息
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
出版信息
Infect Agent Cancer. 2025 Apr 2;20(1):21. doi: 10.1186/s13027-025-00649-z.
PURPOSE
This study aims to explore the contrasting trends of decreasing cervical cancer (CC) rates among women and increasing oropharyngeal cancer (OPC) rates among men.
METHODS
The analysis examines public health initiatives, including CC screening programs and HPV vaccination efforts, alongside the changing epidemiology of OPC.
RESULTS
Declines in CC incidence are attributed to improved screening and HPV vaccination. Conversely, OPC rates are rising among men, linked primarily to HPV infection and lack of established screening programs. Data indicate a higher OPC burden in men compared to CC in women in several countries.
CONCLUSION
Addressing the rising OPC trend requires a multifaceted approach, including gender-neutral HPV vaccination, the development of OPC screening methods, and increased public awareness. Sustained efforts in HPV-related cancer prevention are crucial to mitigate these opposing trends.
目的
本研究旨在探讨女性宫颈癌（CC）发病率下降与男性口咽癌（OPC）发病率上升这两种相反的趋势。
方法
该分析考察了公共卫生举措，包括宫颈癌筛查项目和人乳头瘤病毒（HPV）疫苗接种工作，以及口咽癌不断变化的流行病学情况。
结果
宫颈癌发病率的下降归因于筛查的改善和HPV疫苗接种。相反，男性口咽癌发病率正在上升，主要与HPV感染及缺乏既定的筛查项目有关。数据表明，在几个国家中，男性口咽癌负担高于女性宫颈癌。
结论
应对口咽癌发病率上升的趋势需要采取多方面的方法，包括不分性别的HPV疫苗接种、口咽癌筛查方法的开发以及提高公众意识。在与HPV相关的癌症预防方面持续努力对于缓解这些相反的趋势至关重要。
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