Zong Xuelian, Liu Huiping, Zhao Xiaoyun
Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People'S Liberation Army, Lanzhou, China.
Department of Pediatrics, The 940th Hospital of Joint Logistics Support Force of Chinese People'S Liberation Army, No. 333 Nanbinhe Road, Qilihe District, Lanzhou, 730050, Gansu, China.
Eur J Med Res. 2025 Apr 2;30(1):230. doi: 10.1186/s40001-025-02461-2.
Voxel-based morphometry (VBM) reveals diverse alterations in gray matter volume in acute lymphoblastic leukemia (ALL) patients after chemotherapy. However, the reported results are inconsistent. Therefore, our objective was to conduct a meta-analysis to synthesize findings from existing VBM studies and identify consistent patterns of altered gray matter volume in ALL patients post-chemotherapy.
A systematic search was conducted across PubMed, Web of Knowledge, Embase, Google Scholar, and CNKI for VBM studies that compared ALL patients post-chemotherapy with healthy controls (HCs) up to April 1, 2024. Significant cluster coordinates were extracted for comprehensive analysis.
We included 7 studies involving 143 ALL patients post-chemotherapy and 140 HCs. ALL patients who underwent chemotherapy presented decreased gray matter volume in the left caudate nucleus, left calcarine fissure/surrounding cortex, left precentral gyrus and right anterior thalamic projections. Jackknife sensitivity analysis validated the robustness of these findings.
This meta-analysis revealed consistent gray matter volume alterations in ALL patients post-chemotherapy, emphasizing the need to explore their underlying mechanisms and long-term effects on cognitive and neurological health.
基于体素的形态学测量（VBM）揭示了急性淋巴细胞白血病（ALL）患者化疗后灰质体积的多种变化。然而，报道的结果并不一致。因此，我们的目的是进行一项荟萃分析，以综合现有VBM研究的结果，并确定ALL患者化疗后灰质体积改变的一致模式。
在PubMed、Web of Knowledge、Embase、谷歌学术和中国知网中进行系统检索，以查找截至2024年4月1日将化疗后的ALL患者与健康对照（HC）进行比较的VBM研究。提取显著的簇坐标进行综合分析。
我们纳入了7项研究，涉及143例化疗后的ALL患者和140例HC。接受化疗的ALL患者左侧尾状核、左侧距状裂/周围皮质、左侧中央前回和右侧丘脑前投射的灰质体积减少。留一法敏感性分析验证了这些发现的稳健性。
这项荟萃分析揭示了ALL患者化疗后灰质体积的一致变化，强调需要探索其潜在机制以及对认知和神经健康的长期影响。
