Delamere N A, Paterson C A
Curr Eye Res. 1985 Apr;4(4):447-52. doi: 10.3109/02713688509025159.
The utility of 45Ca efflux studies to examine lens calcium balance is limited because of the dominant contribution of efflux from the extracellular space of the lens. On the other hand, examination of lens 45Ca uptake characteristics can generate valuable information regarding the mechanism by which calcium is largely restricted from the intracellular compartment. Such studies have enabled us to demonstrate that the access of calcium to the intracellular compartment is dependent to some extent upon the concentration of calcium in the extracellular environment. Additionally, experimental evidence speaks against extracellular binding of calcium. Finally, lens membrane permeability to calcium appears to be independent of membrane voltage.
由于晶状体细胞外空间的钙流出起主要作用，利用45Ca流出研究来检测晶状体钙平衡受到限制。另一方面，检测晶状体45Ca摄取特征可以产生关于钙在很大程度上被限制进入细胞内区室的机制的有价值信息。这些研究使我们能够证明，钙进入细胞内区室在一定程度上取决于细胞外环境中的钙浓度。此外，实验证据反驳了钙的细胞外结合。最后，晶状体膜对钙的通透性似乎与膜电压无关。
