Delamere N A, Paterson C A
Exp Eye Res. 1985 Jul;41(1):11-7. doi: 10.1016/0014-4835(85)90090-9.
Lens 45Ca uptake was shown to increase when the external calcium concentration was less than 1 mM, suggesting that calcium ions themselves are able to interact with lens membranes in a way that influences the mechanism of calcium permeability. Strontium ions, added to a calcium-deficient bathing solution, were shown to attenuate the increased 45Ca uptake by the lens. There was no evidence for extracellular binding of calcium. Lens membrane permeability to calcium appeared not to be voltage-dependent since 45Ca uptake was not affected when the lens was depolarized by high potassium solutions. Calcium channel blockers were shown not to reduce the increased calcium leak resulting from exposure of the lens to a calcium-deficient medium.
当外部钙浓度低于1 mM时，晶状体对45Ca的摄取增加，这表明钙离子自身能够以影响钙通透性机制的方式与晶状体膜相互作用。向缺钙的浴液中添加锶离子后，晶状体对45Ca摄取的增加有所减弱。没有证据表明钙存在细胞外结合。晶状体膜对钙的通透性似乎不依赖于电压，因为当晶状体被高钾溶液去极化时，45Ca摄取不受影响。研究表明，钙通道阻滞剂并不能减少晶状体暴露于缺钙培养基后导致的钙泄漏增加。
