Galal Sara A, Kotb Hend G, Kamel Radwa O M, Elsadek Hala M, Hafiz Hala S A, Nassef Eman M, Kasim Sammar A, Akab Samah M, Abdel Sattar Ahmed S, Ahmed Laila A
Dermatology and Venereology Department, Faculty of Medicine for Girls, El-Zahraa Hospital, Al-Azhar University, Cairo, Egypt.
Internal Medicine Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Skin Appendage Disord. 2025 Apr;11(2):103-111. doi: 10.1159/000539924. Epub 2024 Sep 9.
Chronic renal failure can impact various body systems, including the skin and its appendages. Patients with uremic conditions have been observed to experience a variety of nail changes. This study was conducted to evaluate the presence and type of fingernail changes in patients with end-stage renal failure (ESRF) on regular hemodialysis (HD) by nail dermoscopy.
A total of 100 patients with ESRF on regular HD three times a week. Nails were examined by dermoscopy for the presence of subtle nail changes.
Nail changes were found in 91% of patients, while 9% did not have nail changes. The most common dermoscopic findings were as follows; scales in lateral nail fold in 91% of the patients, dry cuticle in 84%, onychoschizia in 72%, and longitudinal striation in 69%. There was no significant relation between nail changes and sex, duration of HD, and albumin level.
Patients with end-stage renal disease on HD are more likely to experience nail disorders. Scales in LNF, dry cuticle, onychoschizia, longitudinal striation, terry's nails, and half-and-half nails were the most common nail changes in HD patients.
慢性肾衰竭会影响包括皮肤及其附属器在内的多个身体系统。已观察到尿毒症患者会出现多种指甲变化。本研究旨在通过指甲皮肤镜检查评估接受定期血液透析（HD）的终末期肾衰竭（ESRF）患者指甲变化的存在情况及类型。
共有100例每周进行3次定期HD的ESRF患者。通过皮肤镜检查指甲以确定是否存在细微的指甲变化。
91%的患者出现指甲变化，9%的患者未出现指甲变化。最常见的皮肤镜检查结果如下：91%的患者甲皱襞外侧有鳞屑，84%有干燥角质层，72%有甲裂片形，69%有纵嵴。指甲变化与性别、HD持续时间和白蛋白水平之间无显著关系。
接受HD的终末期肾病患者更易出现指甲疾病。甲皱襞外侧鳞屑、干燥角质层、甲裂片形、纵嵴、泰瑞氏指甲和对半甲是HD患者最常见的指甲变化。
