Giraldo Samuel Santiago Parra, López Rut Amparo Vergara, Hoz-Herazo Haydee De La, Pla Enrique Carlos Ruiz, Bayona-Pacheco Brayan, De La Hoz Juan Jose Espitia
Division of Health Sciences, Department of Medicine, Universidad del Norte, Barranquilla 081007, Colombia.
Unidad de Patología Diagnostica UPC, Barranquilla 080001, Colombia.
Ecancermedicalscience. 2025 Jan 22;19:1831. doi: 10.3332/ecancer.2025.1831. eCollection 2025.
Dedifferentiated liposarcoma (DDLPS) is a rare mesenchymal neoplasm that accounts for approximately 20% of soft tissue sarcomas in the human body. This case report emphasises a high-grade DDLPS with a retroperitoneal location and its unexpected recurrence in a 72-year-old male patient more than 10 years after the primary tumour. This case is particularly significant because of the anomalous presentation of the tumour recurrence time that is complemented by the unusual histologic features of the initial neoplasm, which raises new questions about the biological behaviour of the disease, the clinical course and the management of this pathology.
The report seeks to highlight the important and unusual aspects of the pathology that can contribute to a better understanding of its evolution, allowing informed clinical decisions to improve the patient's quality of life and prognosis.
去分化脂肪肉瘤（DDLPS）是一种罕见的间叶性肿瘤，约占人体软组织肉瘤的20%。本病例报告着重介绍了一名72岁男性患者，其原发性肿瘤发生10多年后，出现了一例位于腹膜后的高级别DDLPS及其意外复发情况。该病例尤为重要，因为肿瘤复发时间异常，且初始肿瘤具有不寻常的组织学特征，这引发了关于该疾病生物学行为、临床病程及病理处理的新问题。
本报告旨在突出该病理学的重要且不寻常的方面，有助于更好地理解其演变过程，从而做出明智的临床决策，以提高患者的生活质量和预后。
