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内侧扩展杏仁核及相关前脑中枢中Otp谱系儿茶酚胺能神经元的发育。

Development of catecholaminergic neurons of Otp-lineage in the medial extended amygdala and related forebrain centers.

作者信息

Morales Lorena, Desfilis Ester, Medina Loreta

机构信息

Department of Medicina Experimental, Universitat de Lleida, Lleida, Spain.

Laboratory of Evolutionary Developmental Neurobiology, Lleida's Institute for Biomedical Research-Dr. Pifarré Foundation (IRBLleida), Lleida, Spain.

出版信息

Front Neuroanat. 2025 Mar 19;19:1553952. doi: 10.3389/fnana.2025.1553952. eCollection 2025.

DOI:10.3389/fnana.2025.1553952
PMID:40177299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11961924/
Abstract

Catecholaminergic (CA) neurons of the medial extended amygdala, preoptic region and adjacent alar hypothalamus have been involved in different aspects of social behavior, as well as in modulation of homeostasis in response to different stressors. Previous data suggested that at least some CA neurons of the medial extended amygdala could originate in a hypothalamic embryonic domain that expresses the transcription factor Otp. To investigate this, we used Otp-eGFP mice (with permanent labeling of GFP in Otp cells) to analyze coexpression of GFP and tyrosine hydroxylase (TH) throughout ontogenesis by way of double immunofluorescence. Our results provide evidence that some forebrain CA cells belong to the Otp lineage. In particular, we found small subpopulations of TH cells that coexpress GFP within the medial extended amygdala, the periventricular preoptic area, the paraventricular hypothalamus, the periventricular hypothalamus, as well as some subdivisions of the basal hypothalamus. In some of the Otp cells, such as those of extended amygdala, the expression of TH appears to be transitory, in agreement with previous studies. The results open interesting questions about the role of these Otp versus non-Otp catecholaminergic subpopulations during development, network integration and in modulation of different functions, including homeostasis and social behaviors.

摘要

内侧延伸杏仁核、视前区和邻近的下丘脑翼的儿茶酚胺能（CA）神经元参与了社会行为的不同方面，以及对不同应激源的内稳态调节。先前的数据表明，内侧延伸杏仁核的至少一些CA神经元可能起源于表达转录因子Otp的下丘脑胚胎区域。为了对此进行研究，我们使用Otp-eGFP小鼠（Otp细胞中GFP的永久标记）通过双重免疫荧光分析在整个个体发育过程中GFP和酪氨酸羟化酶（TH）的共表达。我们的结果提供了证据，表明一些前脑CA细胞属于Otp谱系。特别是，我们在内侧延伸杏仁核、室周视前区、室旁下丘脑、室周下丘脑以及下丘脑基部的一些亚区中发现了共表达GFP的TH细胞小亚群。在一些Otp细胞中，如延伸杏仁核的细胞，TH的表达似乎是短暂的，这与先前的研究一致。这些结果提出了关于这些Otp与非Otp儿茶酚胺能亚群在发育、网络整合以及包括内稳态和社会行为在内的不同功能调节中的作用的有趣问题。

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