Jung Josephine, Patel Sabina, Khan Azharul, Baamonde Alba Diaz, Mirallave-Pescador Ana, Chowdhury Yasir A, Bell David, Malik Irfan, Thomas Nick, Grahovac Gordan, Vergani Francesco, Ahmed Aminul I, Lavrador José Pedro
Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Neurosciences Clinical Trials Unit, King's College Hospital NHS Foundation Trust, London, UK.
Brain Spine. 2025 Mar 14;5:104234. doi: 10.1016/j.bas.2025.104234. eCollection 2025.
Spinal Cord Injury (SCI) has devastating consequences for patients and their families. Over the last few decades, a renewed interest in the utilization of non-invasive and cost-effective therapeutic technologies in the management of patients with SCI has emerged. This includes stimulation with navigated transcranial magnetic stimulation (nTMS) in order to improve the outcome for these patients alongside with existing clinical tools. nTMS has shown encouraging preliminary results in both clinical assessment and rehabilitation (motor and pain) of patients with SCI. However, different protocols - stimulation parameters, length of treatment and combination with other modalities - and patient selection criteria hampered definitive conclusions. So far, none of these have been adapted in regular clinical practice. In this article, we provide an overview on different assessment and therapeutic strategies using nTMS and review their effectiveness.
脊髓损伤（SCI）对患者及其家庭具有毁灭性后果。在过去几十年中，人们对利用非侵入性且经济高效的治疗技术来管理脊髓损伤患者重新产生了兴趣。这包括使用导航经颅磁刺激（nTMS）进行刺激，以便与现有的临床工具一起改善这些患者的治疗效果。nTMS在脊髓损伤患者的临床评估和康复（运动和疼痛方面）中已显示出令人鼓舞的初步结果。然而，不同的方案——刺激参数、治疗时长以及与其他方式的联合——以及患者选择标准阻碍了得出明确结论。到目前为止，这些方法均未在常规临床实践中得到应用。在本文中，我们概述了使用nTMS的不同评估和治疗策略，并综述了它们的有效性。
