同时出现的非运动症状不影响帕金森病运动日记的总体效度，但会影响其解读。
Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary.
作者信息
Andersson Hampus, Bremer Alexander, Gandor Florin, Ebersbach Georg, Löhle Matthias, Odin Per, Storch Alexander
机构信息
Division of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Department of Neurology, University of Rostock, Rostock, Germany.
出版信息
Mov Disord Clin Pract. 2025 Apr 3;12(7):979-84. doi: 10.1002/mdc3.70061.
BACKGROUND
Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.
OBJECTIVE
This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).
METHODS
A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.
RESULTS
Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.
CONCLUSIONS
Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.
背景
运动波动通常使用帕金森病（PD）家庭日记进行记录。然而，与临床观察者相比，该日记的有效性有限。
目的
本研究剖析了非运动症状（NMS）对PD家庭运动日记与临床观察者之间方法间一致性的影响（外部效度标准）。
方法
在晚期PD患者中进行了一项前瞻性观察性VALIDATE-PD队列研究，通过使用家庭日记（关期、开期、异动状态）和非运动日记（11种关键NMS）每小时同时评分来评估症状严重程度。比较了有和没有同时出现NMS的时间段之间的测试效度指标（准确性和科恩κ系数）。
结果
分析了47名参与者的487个每小时时间段。运动日记的方法间一致性（准确性、科恩κ系数）与同时出现的NMS无关，但同时出现的NMS会反向影响运动关期和开期状态的错误评分。
结论
同时出现的NMS不会影响总体效度，但会影响PD家庭运动日记的解读。
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