德国普通人群中甲状旁腺功能减退患者问卷（HPQ28）的标准值。
Normative values for the hypoparathyroidism patient questionnaire (HPQ28) in the German general population.
作者信息
Trummer Christian, Blaschke Martina, Quint Deborah, Schulz Maxi, Herrmann-Lingen Christoph, Büttner Matthias, Siggelkow Heide
机构信息
Clinic of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, 8036, Austria.
出版信息
J Patient Rep Outcomes. 2025 Apr 3;9(1):38. doi: 10.1186/s41687-025-00868-3.
BACKGROUND
Patients with hypoparathyroidism (HypoPT) suffer from several complaints and reduced quality of life (QoL), even if disease-specific biochemical parameters are within the target range. To be able to quantify symptoms in HypoPT patients, we recently developed a disease-specific questionnaire, the Hypoparathyroidism Patient Questionnaire with 28 items (HPQ28). The aim of this study was to find normative values for the HPQ28 in the German general population.
METHODS
We tasked an independent market and social research institute to obtain sociodemographic data and HPQ28 results from a representative sample of the German general population. The HPQ28 comprises five scales and three single items. The five scales indicate different areas of complaints: Pain and cramps (PaC) including five items, neurovegetative symptoms (NVS) including five items, loss of vitality (LoV) including six items, depression and anxiety (DaA) including five items, gastro-intestinal symptoms (GiS) including two items and two control items for depression. Three items were not attributable to any of the five scales: numbness and tingling in certain parts of the body (NT), troubled memory (TM), and racing heart (RH).
RESULTS
Mean age (± standard deviation) in the representative general population sample (n = 2506) was 49.5 ± 17.8 years, 51% were female. All scales and single items were affected by gender with women presenting significantly more complaints on every scale and single item in comparison to men (p < 0.01, Mann-Whitney U test). In addition, all scales and single items, except for GiS, were affected by age in males and females (p < 0.001, Spearman's correlation). Regression analyses proved a linear trend in the different scores regarding age and gender (p < 0.05 except for age on the GiS scale).
CONCLUSIONS
We present data from the first application of the HPQ28 in a representative sample of the German general population. Almost all scales and single item of the HPQ28 were dependent on age and gender, with older individuals and females presenting a higher burden of complaints.
TRIAL REGISTRATION
DRKS, DRKS00027581. Registered 17th of January 2022, https//drks.de/search/de/trial/DRKS00027581.
背景
甲状旁腺功能减退症（HypoPT）患者存在多种不适症状，生活质量（QoL）下降，即便疾病特异性生化指标处于目标范围内。为了能够量化HypoPT患者的症状，我们最近开发了一种疾病特异性问卷，即包含28个条目的甲状旁腺功能减退症患者问卷（HPQ28）。本研究的目的是确定德国普通人群中HPQ28的常模值。
方法
我们委托一家独立的市场和社会研究机构，从德国普通人群的代表性样本中获取社会人口学数据和HPQ28结果。HPQ28包括五个量表和三个单项。这五个量表表明不同的不适领域：疼痛和痉挛（PaC）包括五个条目，神经植物性症状（NVS）包括五个条目，活力丧失（LoV）包括六个条目，抑郁和焦虑（DaA）包括五个条目，胃肠道症状（GiS）包括两个条目以及两个抑郁对照条目。三个条目不归属于五个量表中的任何一个：身体某些部位的麻木和刺痛（NT）、记忆障碍（TM）以及心跳加速（RH）。
结果
在具有代表性的普通人群样本（n = 2506）中，平均年龄（±标准差）为49.5±17.8岁，51%为女性。所有量表和单项均受性别影响，与男性相比，女性在每个量表和单项上的不适症状明显更多（p < 0.01，曼 - 惠特尼U检验）。此外，除GiS外，所有量表和单项在男性和女性中均受年龄影响（p < 0.001，斯皮尔曼相关性）。回归分析证明，不同分数在年龄和性别方面呈线性趋势（除GiS量表上的年龄外，p < 0.05）。
结论
我们展示了HPQ28首次应用于德国普通人群代表性样本的数据。HPQ28的几乎所有量表和单项都依赖于年龄和性别，年龄较大者和女性的不适负担更高。
试验注册
DRKS，DRKS00027581。于2022年1月17日注册，https//drks.de/search/de/trial/DRKS00027581。
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