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Is Bivalirudin Efficacious in STEMI Patients Undergoing Primary PCI?

作者信息

Valecha Jayesh, Konipineni Sunil, Wankhade Diptish, Kumbhojkar Rahul, Shivakumar Divya, Cyntia Lima Fonseca Rodrigues Amanda

机构信息

Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA.

Department of Internal Medicine, Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine.

出版信息

Cardiovasc Drugs Ther. 2025 Apr 3. doi: 10.1007/s10557-025-07692-3.

DOI:10.1007/s10557-025-07692-3
PMID:40178749
Abstract
摘要

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Is Bivalirudin Efficacious in STEMI Patients Undergoing Primary PCI?比伐卢定在接受直接经皮冠状动脉介入治疗的ST段抬高型心肌梗死患者中是否有效？
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Bivalirudin versus heparin with or without glycoprotein IIb/IIIa inhibitors in patients with STEMI undergoing primary percutaneous coronary intervention: pooled patient-level analysis from the HORIZONS-AMI and EUROMAX trials.比伐卢定与肝素联合或不联合糖蛋白 IIb/IIIa 抑制剂用于行直接经皮冠状动脉介入治疗的 ST 段抬高型心肌梗死患者：来自 HORIZONS-AMI 和 EUROMAX 试验的汇总患者水平分析。
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Meta-analysis of randomized clinical trials comparing bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention and in patients with ST-segment elevation myocardial infarction.经皮冠状动脉介入治疗和 ST 段抬高型心肌梗死患者中比伐卢定与肝素加糖蛋白 IIb/IIIa 抑制剂比较的随机临床试验的荟萃分析。
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Bivalirudin Versus Heparin Monotherapy in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Study-level Meta-analysis of Randomized Controlled Trials.比伐卢定与肝素单药治疗在接受直接经皮冠状动脉介入治疗的ST段抬高型心肌梗死患者中的疗效比较：一项随机对照试验的研究水平荟萃分析
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Bivalirudin in patients undergoing primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: outcomes in a large real-world population.替罗非班在急性 ST 段抬高型心肌梗死患者行直接经皮冠状动脉介入治疗中的应用：一项大型真实世界人群的结局研究。
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本文引用的文献

1
Trial sequential analysis: novel approach for meta-analysis.序贯试验分析：荟萃分析的新方法。
Anesth Pain Med (Seoul). 2021 Apr;16(2):138-150. doi: 10.17085/apm.21038. Epub 2021 Apr 30.
2
Trial Sequential Analysis in systematic reviews with meta-analysis.系统评价与Meta分析中的序贯试验分析。
BMC Med Res Methodol. 2017 Mar 6;17(1):39. doi: 10.1186/s12874-017-0315-7.
3
Common Statistical Pitfalls in Basic Science Research.基础科学研究中常见的统计陷阱
J Am Heart Assoc. 2016 Sep 29;5(10):e004142. doi: 10.1161/JAHA.116.004142.
4
False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review.应用和未应用试验序贯分析的Cochrane系统评价中的假阳性结果：一项实证综述
BMJ Open. 2016 Aug 12;6(8):e011890. doi: 10.1136/bmjopen-2016-011890.
5
Basic concepts for sample size calculation: Critical step for any clinical trials!样本量计算的基本概念：任何临床试验的关键步骤！
Saudi J Anaesth. 2016 Jul-Sep;10(3):328-31. doi: 10.4103/1658-354X.174918.
6
Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses.明显结论性的荟萃分析可能并非结论性的——在明显结论性的新生儿荟萃分析中，对累积数据进行重复测试导致随机误差风险的试验序贯分析调整。
Int J Epidemiol. 2009 Feb;38(1):287-98. doi: 10.1093/ije/dyn188. Epub 2008 Sep 29.