Phytochemical studies of Gerbera jamesonii and evaluation of anti-inflammatory potential in formaldehyde-induced arthritis in rats.

In plants, numerous intricate and structurally diverse phytochemicals are found naturally. The adoption of traditional herbal medicines for many ailments in recent years has prompted researchers to look into the medicinal properties of numerous plants. Although the Asteraceae family has a wide range of significant pharmacological benefits, its antioxidant and antibacterial properties are the most significant. The goal of this study was to ascertain the phytochemical profiling and investigation of anti-arthritic pursuits of Gerbera jamesonii. GC-MS analysis was performed to screen the fingerprints of bioactive compounds. The efficacy of ethanol extract against formaldehyde-induced inflammation in rats was assessed in an in vivo investigation using oral doses of 250-, 500- and 800 mg/kg. The study lasted for 29 days, Hematological and biochemical evaluations were conducted on blood and serum samples. Gerbera jamesonii ethanolic extract (GJE) extract treatment dose dependently decreased the paw inflammation, paw diameter and arthritic score. GJE treatment downregulated the mRNA and protein expression of inflammatory cytokines. Radiological and histo-pathological assessments revealed that GJE treatment effectively reversed the histological and radiological alterations induced by formaldehyde exposure, demonstrating a significant recovery. In the light of above findings, it is suggested that Gerbera jamesonii might be useful in the treatment of inflammatory diseases.