危重症、大手术及其他住院情况与预期寿命(包括健康预期寿命和残疾预期寿命)
Critical Illness, Major Surgery, and Other Hospitalizations and Active and Disabled Life Expectancy.
作者信息
Gill Thomas M, Zang Emma X, Leo-Summers Linda, Gahbauer Evelyne A, Becher Robert D, Ferrante Lauren E, Han Ling
机构信息
Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Department of Sociology, Yale University, New Haven, Connecticut.
出版信息
JAMA Netw Open. 2025 Apr 1;8(4):e254208. doi: 10.1001/jamanetworkopen.2025.4208.
IMPORTANCE
Estimates of active and disabled life expectancy, defined as the projected number of remaining years without and with disability in essential activities of daily living, are commonly used by policymakers to forecast the functional well-being of older persons.
OBJECTIVE
To determine how estimates of active and disabled life expectancy differ based on exposure to intervening illnesses and injuries (or events).
DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study was conducted in south-central Connecticut from March 1998 to December 2021 among 754 community-living persons aged 70 years or older who were not disabled. Data were analyzed from January 25 to September 18, 2024.
EXPOSURES
Exposure to intervening events, which included critical illness, major elective and nonelective surgical procedures, and hospitalization for other reasons, was assessed each month.
MAIN OUTCOMES AND MEASURES
Disability in 4 essential activities of daily living (bathing, dressing, walking, and transferring) was ascertained each month. Active and disabled life expectancy were estimated using multistate life tables under a discrete-time Markov process assumption.
RESULTS
The study included 754 community-living older persons who were not disabled (mean [SD] age, 78.4 [5.3] years; 487 female [64.6%]; 67 Black [8.9%], 4 Hispanic [0.5%], 682 non-Hispanic White [90.5%], and 1 other race [0.1%]). Within 5-year age increments from 70 to 90 years, active life expectancy decreased monotonically as the number of admissions for critical illness and other hospitalization increased. For example, at age 70 years, sex-adjusted active life expectancy decreased from 14.6 years (95% CI, 13.9-15.2 years) in the absence of a critical illness admission to 11.3 years (95% CI, 10.3-12.2 years), 8.1 years (95% CI, 6.3-9.9 years), and 4.0 years (95% CI, 2.6-5.7 years) in the setting of 1, 2, or 3 or more critical illness admissions, respectively. Corresponding values for other hospitalization were 19.4 years (95% CI, 18.0-20.8 years), 13.5 years (95% CI, 12.2-14.7 years), 10.0 years (95% CI, 8.9-11.2 years), and 7.0 years (95% CI, 6.1-7.9 years), respectively. Consistent monotonic reductions were observed for sex-adjusted estimates in active life expectancy for nonelective but not elective surgical procedures as the number of admissions increased; for example, at age 70 years, estimates of active life expectancy were 13.9 years (95% CI, 13.3-14.5 years), 11.7 years (95% CI, 10.5-12.8 years), and 9.2 years (95% CI, 7.4-11.0 years) for 0, 1, and 2 or more nonelective surgical admissions, respectively; corresponding values were 13.4 years (95% CI, 12.8-3-14.1 years), 14.6 years (95% CI, 13.5-15.5 years), and 12.6 years (95% CI, 11.5-13.8 years) for elective surgical admissions. Sex-adjusted disabled life expectancy decreased as the number of admissions increased for critical illness and other hospitalization but not for nonelective or elective surgical procedures; for example, at age 70 years, disabled life expectancy decreased from 4.4 years (95% CI, 3.5-5.8 years) in the absence of other hospitalization to 3.4 years (95% CI, 2.8-4.1 years), 3.4 years (95% CI, 2.7-4.2 years), and 2.3 years (95% CI, 1.9-2.8 years) in the setting of 1, 2, or 3 or more other hospitalizations, respectively.
CONCLUSIONS AND RELEVANCE
This study found that active life expectancy among community-living older persons who were not disabled was considerably diminished in the setting of serious intervening illnesses and injuries. These findings suggest that prevention and more aggressive management of these events, together with restorative interventions, may be associated with improved functional well-being among older persons.
重要性
活动预期寿命和失能预期寿命的估计值,即预计在日常生活基本活动中无残疾和有残疾的剩余年数,常被政策制定者用于预测老年人的功能健康状况。
目的
确定基于是否经历介入性疾病和损伤(或事件),活动预期寿命和失能预期寿命的估计值如何不同。
设计、地点和参与者:这项前瞻性队列研究于1998年3月至2021年12月在康涅狄格州中南部对754名70岁及以上未失能的社区居住者进行。数据于2024年1月25日至9月18日进行分析。
暴露因素
每月评估介入性事件的暴露情况,包括危重病、重大择期和非择期手术以及因其他原因住院。
主要结局和测量指标
每月确定日常生活4项基本活动(洗澡、穿衣、行走和转移)中的失能情况。在离散时间马尔可夫过程假设下,使用多状态生命表估计活动预期寿命和失能预期寿命。
结果
该研究纳入了754名未失能的社区居住老年人(平均[标准差]年龄,78.4[5.3]岁;487名女性[64.6%];67名黑人[8.9%],4名西班牙裔[0.5%],682名非西班牙裔白人[90.5%],以及1名其他种族[0.1%])。在70至90岁每5岁年龄递增范围内,随着危重病和其他住院次数的增加,活动预期寿命单调下降。例如,在70岁时,调整性别后的活动预期寿命在未发生危重病住院时为14.6年(95%置信区间,13.9 - 15.2年),在发生1次、2次或3次及以上危重病住院时分别降至11.3年(95%置信区间,10.3 - 12.2年)、8.1年(95%置信区间,6.3 - 9.9年)和4.0年(95%置信区间,2.6 - 5.7年)。其他住院的相应值分别为19.4年(95%置信区间,18.0 - 20.8年)、13.5年(95%置信区间,12.2 - 14.7年)、10.0年(95%置信区间,8.9 - 11.2年)和7.0年(95%置信区间,6.1 - 7.9年)。随着非择期而非择期手术住院次数的增加,调整性别后的活动预期寿命估计值持续单调下降;例如,在70岁时,非择期手术住院0次、1次和2次及以上时,活动预期寿命估计值分别为13.9年(95%置信区间,13.3 - 14.5年)、11.7年(95%置信区间,10.5 - 12.8年)和9.2年(95%置信区间,7.4 - 11.0年);择期手术住院的相应值分别为13.4年(95%置信区间,12.8 - 14.1年)、14.6年(95%置信区间,13.5 - 15.5年)和12.6年(95%置信区间。随着危重病和其他住院次数的增加,调整性别后的失能预期寿命下降,但非择期或择期手术住院次数增加时则不然;例如,在70岁时,未发生其他住院时失能预期寿命为4.4年(95%置信区间,3.5 - 5.8年),在发生1次、2次或3次及以上其他住院时分别降至3.4年(95%置信区间,2.8 - 4.1年)、3.4年(95%置信区间,2.7 - 4.2年)和2.3年(95%置信区间,1.9 - 2.8年)。
结论和相关性
本研究发现,在发生严重介入性疾病和损伤的情况下,未失能的社区居住老年人的活动预期寿命会大幅缩短。这些发现表明,对这些事件进行预防和更积极的管理,以及恢复性干预措施,可能与改善老年人的功能健康状况相关。